Results 61 to 70 of about 1,222,668 (263)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Hierarchical Ring Network design
Theory of Computing Systems, 2003 A hierarchical ring network is obtained from a ring network by appending at most one subsidiary ring to each node of the ring and, recursively, to each node of each subsidiary ring. The depth d is the number of levels of the recursive appending of subsidiary rings.
Bermond, Jean-Claude +2 more
openaire +3 more sources
Bicriteria network design problems [PDF]
Journal of Algorithms, 1995 We study a general class of bicriteria network design problems. A generic problem in this class is as follows: Given an undirected graph and two minimization objectives (under different cost functions), with a budget specified on the first objective, find a subgraph from a given subgraph-class that minimizes the second objective subject to the budget ...
Marathe, M. V. +5 more
openaire +5 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
, 2009 We consider the problem of designing a distribution network to facilitate the repeated movement of shipments from many origins to many destinations. A sufficient number of the origin-destination shipments require less than the capacity of a vehicle, so that consolidation of shipments is economical.
Kleywegt, Anton J. +2 more
openaire +4 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Network design with grooming constraints
Electronic Notes in Discrete Mathematics, 2004 Abstract Networks are physically and logically decomposed into layers with different technological features. Often, the routing of a demand through a non-multiplexing layer is made by grooming several demands at another, multiplexing-capable layer, thus using less capacity on the former but more on the latter.
BELOTTI P., MALUCELLI, FEDERICO
openaire +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
DesIGN: Design Inspiration from Generative Networks [PDF]
, 2019 Can an algorithm create original and compelling fashion designs to serve as an inspirational assistant? To help answer this question, we design and investigate different image generation models associated with different loss functions to boost creativity in fashion generation.
Othman Sbai +4 more
openaire +2 more sources