Results 101 to 110 of about 4,643,840 (321)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
New Optical Splitter Design for Network Scalability and Flexibility [PDF]
, 2009 In this paper, we present the design of two optical splitter which are 2x3 optical splitter-combine and Multi Ratio Optical Splitter (MROS) based on waveguide with SU-8 polymer material.
Syuhaimi, Mohammad
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Fair and efficient network dimensioning with the reference point methodology
Journal of Telecommunications and Information Technology, 2006 The dimensioning of telecommunication networks that carry elastic traffic requires the fulfillment of two conflicting goals: maximizing the total network throughput and providing fairness to all flows.
Włodzimierz Ogryczak +2 more
doaj +1 more source
Economic Optimization of Fiber Optic Network Design in Anchorage [PDF]
, 2016 Presented to the Faculty of the University of Alaska Anchorage in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE, ENGINEERING MANAGEMENTThe wireline telecommunications industry is currently involved in an evolution. Growing
Kintner, Jasen
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Mapping and Developing Service Design Research in the UK. [PDF]
, 2014 This report is the outcome of the Service Design Research UK (SDR UK) Network with Lancaster University as primary investigator and London College of Communication, UAL as co-investigator.
Prendiville, Alison +2 more
core +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Networked PID control design : a pseudo-probabilistic robust approach [PDF]
, 2009 Networked Control Systems (NCS) are feedback/feed-forward control systems where control components (sensors, actuators and controllers) are distributed across a common communication network.
Katebi, M.R., Recalde Camacho, L.
core
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source