The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
Service network design for freight railway transportation: The Chinese case. [PDF]
PLoS One, 2022 Xin X.
europepmc +1 more source
Design of a novel robust adaptive neural network‐based fractional‐order proportional‐integrated‐derivative controller on DC/DC Boost converter [PDF]
, 2023 Mohammad Abdollahzadeh +3 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Resilient and social health service network design to reduce the effect of COVID-19 outbreak. [PDF]
Ann Oper Res, 2023 Hosseini-Motlagh SM +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Viable healthcare supply chain network design for a pandemic. [PDF]
Ann Oper Res, 2022 Alizadeh M +4 more
europepmc +1 more source
A Dual Neural Network Approach to Topology Optimization for Thermal-Electromagnetic Device Design
, 2023 Benjamin A. Jasperson +2 more
openalex +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
An Adaptive Network Design for Advanced Metering Infrastructure in a Smart Grid. [PDF]
Sensors (Basel), 2022 Kim JW, Kim J, Lee J.
europepmc +1 more source