Results 91 to 100 of about 4,728,201 (299)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Constrained Consistency Modeling for Attributed Network Embedding

open access: yesIEEE Access, 2019
Network embedding has emerged as a fundamental approach to network analysis tasks. Its main purpose is to learn a suitable mapping function to convert nodes in networks into a low-dimensional representations.
Xuan Zang   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Multi-View Network Representation Learning Algorithm Research

open access: yesAlgorithms, 2019
Network representation learning is a key research field in network data mining. In this paper, we propose a novel multi-view network representation algorithm (MVNR), which embeds multi-scale relations of network vertices into the low dimensional ...
Zhonglin Ye   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

EMBEDDINGS INTO THE PANCAKE INTERCONNECTION NETWORK [PDF]

open access: yesParallel Processing Letters, 2002
Owing to its nice properties, the pancake is one of the Cayley graphs that were proposed as alternatives to the hypercube for interconnecting processors in parallel computers. In this paper, we present embeddings of rings, grids and hypercubes into the pancake with constant dilation and congestion.
openaire   +4 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Virtual network embedding method based on node delay perception

open access: yesIET Networks
Wireless virtual network uses software defined network and network function virtualisation technologies to create multiple logically isolated virtual networks on a physical wireless network.
Yaning Wang, Hui Zhi
doaj   +1 more source

Enhancing Attributed Network Embedding via Similarity Measure

open access: yesIEEE Access, 2019
Network embedding aims to represent network structural and attributed information with low-dimensional vectors, which has been demonstrated to be beneficial for many network analysis tasks, such as link prediction, node classification and visualization ...
Bin Yu   +4 more
doaj   +1 more source

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