Results 101 to 110 of about 8,419,643 (305)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Parametric t-Distributed Stochastic Exemplar-centered Embedding
, 2018 Parametric embedding methods such as parametric t-SNE (pt-SNE) have been widely adopted for data visualization and out-of-sample data embedding without further computationally expensive optimization or approximation. However, the performance of pt-SNE is
A Gisbrecht +5 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Virtual network embedding method based on node delay perception
IET NetworksWireless virtual network uses software defined network and network function virtualisation technologies to create multiple logically isolated virtual networks on a physical wireless network.
Yaning Wang, Hui Zhi
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Multi-View Network Representation Learning Algorithm Research
Algorithms, 2019 Network representation learning is a key research field in network data mining. In this paper, we propose a novel multi-view network representation algorithm (MVNR), which embeds multi-scale relations of network vertices into the low dimensional ...
Zhonglin Ye +3 more
doaj +1 more source
Compositional Network Embedding
, 2019 Accepted By RecSys ...
Lyu, Tianshu +4 more
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Context Attention Heterogeneous Network Embedding
Computational Intelligence and Neuroscience, 2019 Network embedding (NE), which maps nodes into a low-dimensional latent Euclidean space to represent effective features of each node in the network, has obtained considerable attention in recent years. Many popular NE methods, such as DeepWalk, Node2vec, and LINE, are capable of handling homogeneous networks.
Wei Zhuo +4 more
openaire +2 more sources