Results 71 to 80 of about 914,936 (268)

Phenotypes of Vascular Flow Networks [PDF]

Physical Review Letters, 2019
Complex distribution networks are pervasive in biology. Examples include nutrient transport in the slime mold \emph{Physarum polycephalum} as well as mammalian and plant venation. Adaptive rules are believed to guide development of these networks and lead to a reticulate, hierarchically nested topology that is both efficient and resilient against ...
Henrik Ronellenfitsch, Eleni Katifori
openaire   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Neural Flows in Hopfield Network Approach

Annals of West University of Timisoara: Physics, 2013
In most of the applications involving neural networks, the main problem consists in finding an optimal procedure to reduce the real neuron to simpler models which still express the biological complexity but allow highlighting the main characteristics of ...
Ionescu Carmen, Panaitescu Emilian, Stoicescu Mihai   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A Bayesian Network Model for Origin-Destination Matrices Estimation Using Prior and Some Observed Link Flows

Discrete Dynamics in Nature and Society, 2014
This paper presents a Bayesian network model for estimating origin-destination matrices. Most existing Bayesian methods adopt prior OD matrixes, which are always troublesome to be obtained.
Lin Cheng, Senlai Zhu, Zhaoming Chu, Jingxu Cheng   +3 more
doaj   +1 more source

Identifying and Understanding Scientific Network Flows [PDF]

EPJ Web of Conferences
The High-Energy Physics (HEP) and Worldwide LHC Computing Grid (WLCG) communities have faced significant challenges in understanding their global network flows across the world’s research and education (R&E) networks. This article describes the status of
Attebury Garhan, Babik Marian, Carder Dale, Chown Tim, Hanushevsky Andrew, Hoeft Bruno, Lake Andrew, Lambert Michael, Letts James, McKee Shawn, Newell Karl, Sullivan Tristan   +11 more
doaj   +1 more source

Flow Aggregation for Energy-Aware Ad-Hoc Wireless Networks Respecting QoS Provisions

Journal of Telecommunications and Information Technology, 2020
Emerging communication technologies are now leading developers to design IT systems taking into count their energy-related considerations. Much research performed in the area of ad-hoc wireless networks tends to distribute the flows over all nodes of the
Mustapha Boukrim, Jilali Antari
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source