Results 41 to 50 of about 1,077,678 (246)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Network meta-analysis of treatment regimens for inoperable advanced hepatocellular carcinoma with portal vein invasion [PDF]
, 2018 Ming-Feng Li,1,2,* Henry WC Leung,3,* Agnes LF Chan,4 Shyh-Yau Wang2,* 1Department of Medical Imaging, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan; 2Department of Radiology, An-Nan Hospital, China Medical University, Tainan, Taiwan; 3Department ...
Wang SY, Li MF, Leung HW, Chan AL
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Comparison of Different Systemic Therapeutic Regimes in Resectable Soft-Tissue Sarcoma—Results of a Network Meta-Analysis [PDF]
, 2021 Background: The standard treatment of high-risk soft-tissue sarcoma consists of surgical resection followed by risk-adapted radiation therapy. Further treatment options that may improve local and systemic tumor control, including chemotherapy, are not ...
Johannes Fischer +19 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Off-farm and non-farm employment in Southeast Asian transitional economies and Thailand [PDF]
, 2003 The Development Analysis Network (DAN) is a network of research institutions in Thailand and the Southeast Asian Transitional Economies (SEATE) of Cambodia, Laos and Vietnam. Suggested in this report is that the employment potential of rural off-farm and
Development Analysis Network
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Social Network Analysis: Applications: Event Programme [PDF]
, 2007 This seminar explores a number of current uses and applications of network analysis, including applications in social movement analysis, criminology, socio-linguistics and the study of literary networks.
Social Network, Analysis
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Network Meta-analysis result of sensitivity analysis. [PDF]
, 2023 Network Meta-analysis result of sensitivity analysis.
Kyungsun Chae (17328254) +4 more
core +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source