Results 41 to 50 of about 1,344,082 (280)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Network meta-analysis of balloon angioplasty, nondrug metal stent, drug-eluting balloon, and drug-eluting stent for treatment of infrapopliteal artery occlusive disease

open access: yesDiagnostic and Interventional Radiology, 2016
PURPOSE:We aimed to conduct a network meta-analysis of mixed treatments for the infrapopliteal artery occlusive disease.METHODS:We searched randomized controlled trials (RCTs) regarding balloon angioplasty (BA), nondrug metal stent (NDMS), drug-eluting ...
Yaowen Xiao   +3 more
doaj   +1 more source

Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]

open access: yes, 2019
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke   +4 more
core   +1 more source

Network meta‐analysis of multicomponent interventions [PDF]

open access: yesBiometrical Journal, 2019
AbstractIn network meta‐analysis (NMA), treatments can be complex interventions, for example, some treatments may be combinations of others or of common components. In standard NMA, all existing (single or combined) treatments are different nodes in the network.
Gerta Rücker   +2 more
openaire   +4 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Clinical evidence of sesame (Sesamum indicum L.) products and its bioactive compounds on anthropometric measures, blood pressure, glycemic control, inflammatory biomarkers, lipid profile, and oxidative stress parameters in humans: a GRADE-assessed systematic review and dose–response meta-analysis

open access: yesNutrition & Metabolism
This comprehensive systematic review and meta-analysis aimed to assess the impact of sesame (Sesamum indicum L.) supplementation on cardiovascular disease risk factors.
Ali Jafari   +5 more
doaj   +1 more source

Comparative safety and efficacy of vasopressors for mortality in septic shock: A network meta-analysis

open access: yes, 2015
© 2015, © The Intensive Care Society 2015.Introduction: Septic shock is a life-threatening condition requiring vasopressor agents to support the circulatory system. Several agents exist with choice typically guided by the specific clinical scenario.
Gordon, AC   +3 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Gepants for abortive treatment of migraine: A network meta‐analysis

open access: yesBrain and Behavior, 2020
Objectives To evaluate and compare the efficacy and safety of gepants for abortive treatment of migraine by network meta‐analysis. Materials & Methods Publications, which were randomized controlled trials (RCTs) about gepants for abortive treatment of ...
Peiwei Hong   +3 more
doaj   +1 more source

Multiple Score Comparison: a network meta-analysis approach to comparison and external validation of prognostic scores [PDF]

open access: yes, 2017
BACKGROUND Prediction models and prognostic scores have been increasingly popular in both clinical practice and clinical research settings, for example to aid in risk-based decision making or control for confounding.
Guerra, Beniamino   +3 more
core   +1 more source

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