Results 31 to 40 of about 339,521 (219)

Network meta-analysis-highly attractive but more methodological research is needed

BMC Medicine, 2011
Network meta-analysis, in the context of a systematic review, is a meta-analysis in which multiple treatments (that is, three or more) are being compared using both direct comparisons of interventions within randomized controlled trials and indirect ...
Singh Sonal, Vedula Swaroop S, Puhan Milo A, Li Tianjing, Dickersin Kay   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta‐Analysis, and Network Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cerebral cavernous malformations are complex vascular anomalies in the central nervous system associated with a risk of intracranial hemorrhage.
Basel Musmar, Hamza Salim, Jihad Abdelgadir, Samantha Spellicy, Nimer Adeeb, Ali Zomorodi, Allan Friedman, Issam Awad, Pascal M. Jabbour, David M. Hasan   +9 more
doaj   +1 more source

Subthreshold Depression: A Systematic Review and Network Meta-Analysis of Non-Pharmacological Interventions

Neuropsychiatric Disease and Treatment, 2023
Xiaofei Hao,1,* Yuying Jia,2,* Jie Chen,2 Chuan Zou,1 Cuinan Jiang3 1Department of General Medicine, Chengdu Fifth People’s Hospital, Chengdu, Sichuan, 611130, People’s Republic of China; 2Department of Outpatient, The General Hospital of Western
Hao X, Jia Y, Chen J, Zou C, Jiang C
doaj  

An introduction to Risk of Bias in Network Meta-analysis (RoB NMA) tool [PDF]

Yixue xinzhi zazhi
Existing risk of bias assessment tools are primarily designed for traditional pairwise Meta-analysis and fail to comprehensively evaluate the unique sources of bias risk inherent in network Meta-analysis.
ZHAO Wenshuo, LIU Ming, SHI Jiyuan, LI Lun, YANG Fengwen, XUE Fuzhong, GAO Ya   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ticagrelor Paradox: Systematic Review and Network Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Based on the landmark PLATO (Platelet Inhibition and Patient Outcomes) and TRITON‐TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction) trials ...
Atsuyuki Watanabe, Tadao Aikawa, Yoshihisa Miyamoto, Hiroki A. Ueyama, Tomohiro Fujisaki, Satoshi Shoji, Kaveh Hosseini, Leandro Slipczuk, Alexandros Briasoulis, Polydoros N. Kampaktsis, Jose Wiley, Eric A. Secemsky, Masao Iwagami, Yusuke Tsugawa, Toshiki Kuno   +14 more
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Meta-Network Analysis of Structural Correlation Networks Provides Insights Into Brain Network Development

Frontiers in Human Neuroscience, 2019
Analysis of developmental brain networks is fundamentally important for basic developmental neuroscience. In this paper, we focus on the temporally-covarying connection patterns, called meta-networks, and develop a new mathematical model for meta-network
Xiaohua Xu, Ping He, Pew-Thian Yap, Han Zhang, Jingxin Nie, Dinggang Shen, Dinggang Shen   +6 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source