Results 31 to 40 of about 1,075,188 (246)

Network meta-analysis of balloon angioplasty, nondrug metal stent, drug-eluting balloon, and drug-eluting stent for treatment of infrapopliteal artery occlusive disease [PDF]

, 2016
PURPOSE:We aimed to conduct a network meta-analysis of mixed treatments for the infrapopliteal artery occlusive disease.METHODS:We searched randomized controlled trials (RCTs) regarding balloon angioplasty (BA), nondrug metal stent (NDMS), drug-eluting ...
Zhong Chen, Yaowen Xiao, Lei Kou, Yaoguo Yang   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Estimating the variance for heterogeneity in arm-based network meta-analysis

, 2018
Network meta-analysis can be implemented by using arm-based or contrast-based models. Here we focus on arm-based models and fit them using generalized linear mixed model procedures.
Emlyn R. Williams, James Roger, Madden, L. V., Williams, E. R., Hans-Peter Piepho, Piepho, H.-P., Laurence V. Madden, Roger Payne, Roger, J., Payne, R. W.   +9 more
core   +1 more source

netmeta: An R Package for Network Meta-Analysis Using Frequentist Methods

, 2023
Network meta-analysis compares different interventions for the same condition, by combining direct and indirect evidence derived from all eligible studies.
Theodoros Papakonstantinou, Salanti, Georgia, Adriani Nikolakopoulou, Guido Schwarzer, Rücker, Gerta, Orestis Efthimiou, Nikolakopoulou, Adriani, Efthimiou, Orestis, Gerta Rücker, Georgia Salanti, Papakonstantinou, Theodoros, Balduzzi, Sara, Schwarzer, Guido, Sara Balduzzi   +13 more
core   +1 more source

Demystifying trial networks and network meta-analysis [PDF]

BMJ, 2013
Networks of randomized clinical trials can be evaluated in the context of a network meta-analysis, a procedure that permits inferences into the comparative effectiveness of interventions that may or may not have been evaluated directly against each other.
Edward J, Mills, Kristian, Thorlund, John P A, Ioannidis   +2 more
openaire   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Network meta-analysis of acupuncture for tinnitus

Medicine, 2023
Objective: To provide evidence for medical management of tinnitus based on an assessment of the evidence concerning the effectiveness of acupuncture as a treatment for tinnitus using network meta-analysis (NMA). Methods: We conducted a systematic literature review by searching 8 ...
Lin Ji, Haopeng Zhang, Lihua Wang, Ziming Yin, Jingtu Cen, Yu Guo   +5 more
openaire   +2 more sources