Results 221 to 230 of about 628,285 (376)

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Hypolipidemic effect and mechanism of Hedan tablet based on network pharmacology. [PDF]

J Tradit Chin Med
Huiming HU, Jiajun W, Fangrui T, Yaqi W, Shengxian F, Xuecheng W, Can C, Feng S, Yanchen Z.   +8 more
europepmc   +1 more source

Network pharmacology-based identification of key pharmacological pathways of Yin–Huang–Qing–Fei capsule acting on chronic bronchitis

, 2016
Guohua Yu, Yanqiong Zhang, Ren Weiqiong, Ling Dong, Junfang Li, Ya Geng, Yi Zhang, Defeng Li, Haiyu Xu, Hongjun Yang   +9 more
openalex   +2 more sources

Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease [PDF]

, 2018
Jiansong Fang, Chuipu Cai, Yan-Ting Chai, Jingwei Zhou, Yujie Huang, Li Gao, Qi Wang, Feixiong Cheng   +7 more
openalex   +1 more source

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The placenta expresses much higher levels of PPARγ than fetal adipose tissue. Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus regulate adipogenic genes distinct from endogenous PPARγ. Compromised placental PPARγ leads to fetal adipogenesis deficiency and intrauterine growth restriction, reversible ...
Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong   +17 more
wiley   +1 more source

Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis

, 2016
Alfred D. Nelson, Michael Camilleri, Sakkarin Chirapongsathorn, Priya Vijayvargiya, Nelson Valentin, Andrea Shin, Patricia J. Erwin, Zhen Wang, M. Hassan Murad   +8 more
openalex   +2 more sources

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Advanced Science, Volume 12, Issue 16, April 24, 2025.
This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou   +13 more
wiley   +1 more source

Synergistic mechanism of olaparib and cisplatin on breast cancer elucidated by network pharmacology. [PDF]

Sci Rep
Niu Q, Zhang T.
europepmc   +1 more source

Altered Brain‐Behavior Association During Resting State is a Potential Psychosis Risk Marker

Advanced Science, EarlyView.
The study detects a potential multimodal biomarker that can be promising for identifying early markers of psychosis. It shows a consistent brain‐behavior association between a circuit of interconnected regions and executive function in neurotypical controls and individuals at various stages of psychosis.
Leonardo Fazio, Giuseppe Stolfa, Roberta Passiatore, Angelantonio Tavella, Giuseppe Blasi, Madalina O. Buciuman, Aaron L. Goldman, Shalaila S. Haas, Lana Kambeitz‐Ilankovic, Nikolaos Koutsouleris, Monica Nicoli, Teresa Popolizio, Antonio Rampino, Anne Ruef, Fabio Sambataro, Pierluigi Selvaggi, William Ulrich, Daniel R. Weinberger, Apulian Network on Risk for Psychosis, PRONIA Consortium, Alessandro Bertolino, Linda A. Antonucci, Giulio Pergola   +22 more
wiley   +1 more source

Editorial: The role of genes and network pharmacology in new drug discovery. [PDF]

Front Genet
Mao J.
europepmc   +1 more source