Results 231 to 240 of about 628,285 (376)

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Network pharmacology approach to unveiling the mechanism of berberine in the amelioration of morphine tolerance. [PDF]

J Tradit Chin Med
Shuai H, Zhikang D, Zirui W, Tianfeng H, Yali GE, Jianwen S, Ju G.   +6 more
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Exploration potential sepsis-ferroptosis mechanisms through the use of CETSA technology and network pharmacology. [PDF]

Sci Rep
Shen YZ, Luo B, Zhang Q, Hu L, Hu YC, Chen MH.   +5 more
europepmc   +1 more source

Quantitative Determination of Flexible Pharmacological Mechanisms Based On Topological Variation in Mice Anti-Ischemic Modular Networks

, 2016
Yinying Chen, Yanan Yu, Yingying Zhang, Bing Li, Jun Liu, Dongfeng Li, Ping Wu, Jie Wang, Zhong Wang, Yongyan Wang   +9 more
openalex   +2 more sources

NaBC1 Boron Transporter Enables Myoblast Response to Substrate Rigidity via Fibronectin‐Binding Integrins

Advanced Science, EarlyView.
Cells transduce the rigidity of the environment into biochemical cues through mechanotransductive cascades that modulate cell behavior. Here, a novel role for the boron transporter NaBC1 is identified as a mechanotransducer involved in regulating cell behavior via specific crosstalk with fibronectin‐binding integrins.
Juan Gonzalez‐Valdivieso, Giuseppe Ciccone, Udesh Dhawan, Tezz Quon, Eva Barcelona‐Estaje, Aleixandre Rodrigo‐Navarro, Rafael R. Castillo, Graeme Milligan, Patricia Rico, Manuel Salmeron‐Sanchez   +9 more
wiley   +1 more source

Probing the molecular mechanism of kaempferol in relieving rheumatoid arthritis based on network pharmacology. [PDF]

Sci Rep
Liu H, Lu H, Fan X, Chen S, Chen X, Gao W.   +5 more
europepmc   +1 more source

An Integrated Study on the Antitumor Effect and Mechanism of Triphala Against Gynecological Cancers Based on Network Pharmacological Prediction and In Vitro Experimental Validation [PDF]

, 2018
Yuhang Zhao, Min Wang, Jokyab Tsering, Hanluo Li, Simin Li, Yuepeng Li, Yinghua Liu, Xianda Hu   +7 more
openalex   +1 more source

Single‐Cell Transcriptomes of Immune Cells from Multiple Compartments Redefine the Ontology of Myeloid Subtypes Post‐Stroke

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Using single‐cell sequencing in a murine stroke model (p‐MCAO), three stroke‐specific subpopulations are identified: disease inflammatory macrophage (DIM), disease‐associated microglia (DAM), and CD14+ neutrophils (Neut_Cd14). Detailed analyses reveal that Neut_Cd14 and DIM subtypes are skull‐derived, whereas DAM likely originates from homeostatic ...
Mo Yang, Yixiang Li, Kaibin Shi, Xuezhu Wang, Xiangrong Liu, Xiang Huang, Fu‐Dong Shi, Shaojie Ma, Mingfeng Li, Yilong Wang   +9 more
wiley   +1 more source

Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer's disease. [PDF]

Sci Rep
Gao W, Yang G, Liu X, Hu K, Pan J, Wang X, Zhao Y, Xu Y.   +7 more
europepmc   +1 more source