Results 241 to 250 of about 7,014,814 (396)

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Revealing key antioxidant compounds and mechanisms in Fritillaria Bulbus by metabolomics and network pharmacology. [PDF]

NPJ Sci Food
Guo X, Chen X, Zeng M, Xuan T, Xue J, Chen K, Gong J, Song G, Shen Q.   +8 more
europepmc   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Elucidation of the Hemostatic and Anti-Inflammatory Effects of Walnut Shell Ethanol Extract by Network Pharmacology and Experimental Verification. [PDF]

Food Sci Nutr
He Y, Zhao W, Sun Y, Ma L, Li C, Zheng X, Feng Z, Guo H, Qin L, Zhang Y.   +9 more
europepmc   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Network pharmacology and molecular docking to elucidate the mechanism of antiaging of Platycodon grandiflorus. [PDF]

Medicine (Baltimore)
Liu J, Yang Y, Zhang X, Wan Y.
europepmc   +1 more source

Predicting new indications of compounds with a network pharmacology approach: Liuwei Dihuang Wan as a case study

, 2017
Yin‐Ying Wang, Hong Bai, Runzhi Zhang, Hong Yan, Kang Ning, Xing‐Ming Zhao   +5 more
openalex   +2 more sources

P491 Comparative efficacy on mucosal healing of pharmacological therapies for moderate-to-severe ulcerative colitis, based on prior exposure to tumour necrosis factor antagonists: A systematic review and network meta-analysis [PDF]

, 2018
Paschalis Paschos, Anastasia Katsoula, Όλγα Γιουλεμέ, Απόστολος Τσάπας   +3 more
openalex   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

The mechanism of Shancigu and its monomer in the development of colorectal cancer based on network pharmacology. [PDF]

Sci Rep
Li G, Zhu X, Zhao R, Zhang X, Huang C, Shu M, Liu L, Yuan J.   +7 more
europepmc   +1 more source