Results 251 to 260 of about 7,014,814 (396)

Efficacy and safety of pharmacological interventions in metabolic syndrome: protocol for systematic review and network meta-analysis [PDF]

, 2018
Leonardo Roever, Elmiro Santos Resende, AngelicaLemo Debs Diniz, Nilson Penha‐Silva, João Lucas O’Connell, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Thiago Montes Fidale, Antonio Casella–Filho, Paulo Magno Martins Dourado, Antônio Carlos Palandri Chagas, Sadeq Ali‐Hasan‐Al‐Saegh, Paulo Eduardo Ocke Reis, Rogério de MeloCosta Pinto, Gustavo B.F. Oliveira, Álvaro Avezum, Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antônio José Grande, Celise Denardi, Renato D. Lópes, Nitesh Nerlekar, Shahab Alizadeh, Adrían V. Hernández, Maria Inês da Rosa, Gary Tse, Tong Liu, Giuseppe Biondi‐Zoccai   +32 more
openalex   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics. [PDF]

Chin Med
Meng J, Zhang X, Xiang D, Liang H, Zhao S, Xu L, Yang J, Chen J, Zhang J, Han Y.   +9 more
europepmc   +1 more source

Pharmacological interventions for stress ulcer prophylaxis in critically ill patients: a mixed treatment comparison network meta-analysis and a recursive cumulative meta-analysis

, 2017
Kannan Sridharan, Gowri Sivaramakrishnan, Jerome Gnanaraj   +2 more
openalex   +2 more sources

Comparative Study Of Complex Network Community Structure Algorithms In network Pharmacology Analysis [PDF]

, 2018
Wangping Xiong, Xian Zhou, Bin Nie, Jianqiang Du   +3 more
openalex   +1 more source

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification. [PDF]

Front Chem
Li X, Yang C, Wang L, Ullah I, Liu X, Feng C, Liu Q.   +6 more
europepmc   +1 more source

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

Advanced Science, EarlyView.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou, Yuwei Wang, Yu Liu, Feipeng Zhu, Ge Gao, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Yuting Guan, Virginia Man‐Yee Lee, Jianjun Chen, Jialin Zheng, Qihui Wu   +14 more
wiley   +1 more source

Network pharmacology analyses and corresponding validation of the mechanistic effects of Yangyin Tongnao Granules in ischemic stroke. [PDF]

Sci Rep
Yu J, Chen Q, Dou X, Zhu R, Yang J, Jin W, Wan H, Yu L, Zhang Y.   +8 more
europepmc   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source