Results 61 to 70 of about 7,014,814 (396)

Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation

open access: yesBioscience Reports, 2022
Abstract Objective: Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular
Shuai Shi   +8 more
openaire   +2 more sources

Network Pharmacology and Molecular Docking Study of the Chinese Miao Medicine Sidaxue in the Treatment of Rheumatoid Arthritis

open access: yesDrug Design, Development and Therapy, 2022
Purpose This study aimed to investigate the molecular mechanisms of Compound Sidaxue (SX), a prescription of Chinese Miao medicine, in treating rheumatoid arthritis (RA) using network pharmacology and in vivo experimental approaches.
N. Wu   +9 more
semanticscholar   +1 more source

The heterogeneous pharmacological medical biochemical network PharMeBINet

open access: yesScientific Data, 2022
AbstractHeterogeneous biomedical pharmacological databases are important for multiple fields in bioinformatics. Hetionet is a freely available database combining diverse entities and relationships from 29 public resources. Therefore, it is used as the basis for this project.
Königs, Cassandra   +2 more
openaire   +3 more sources

Based on Network Pharmacology and Gut Microbiota Analysis to Investigate the Mechanism of the Laxative Effect of Pterostilbene on Loperamide-Induced Slow Transit Constipation in Mice

open access: yesFrontiers in Pharmacology, 2022
Background: Pterostilbene (PTE) is a natural polyphenol compound that has been proven to improve intestinal inflammation, but its laxative effect on slow transit constipation (STC) has never been studied.
Zhiwei Yao   +4 more
semanticscholar   +1 more source

A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis [PDF]

open access: yesEvidence-Based Complementary and Alternative Medicine, 2016
As the most familiar type of arthritis and a chronic illness of the joints, Osteoarthritis (OA) affects a great number of people on the global scale. XuanHuSuo powder (XHSP), a conventional herbal formula from China, has been extensively applied in OA treatment. Nonetheless, its pharmacological mechanism has not been completely expounded.
Huaqi Tang   +9 more
openaire   +2 more sources

Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer. [PDF]

open access: yes, 2012
BACKGROUND AND OBJECTIVES: Recurrence in lymph node-negative (pN0) colorectal cancer suggests the presence of undetected occult metastases. Occult tumor burden in nodes estimated by GUCY2C RT-qPCR predicts risk of disease recurrence.
Barkun, Alan   +4 more
core   +2 more sources

Integrating metabolomics and network pharmacology to assess the effects of quercetin on lung inflammatory injury induced by human respiratory syncytial virus

open access: yesScientific Reports, 2023
Quercetin (QR) has significant anti-respiratory syncytial virus (RSV) effects. However, its therapeutic mechanism has not been thoroughly explored. In this study, a lung inflammatory injury model caused by RSV was established in mice.
Ya-Lei Sun   +7 more
doaj   +1 more source

Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer

open access: yesPharmaceuticals, 2022
Liver cancer (LC), a frequently occurring cancer, has become the fourth leading cause of cancer mortality. The small number of reported data and diverse spectra of pathophysiological mechanisms of liver cancer make it a challenging task and a serious ...
Sara Batool   +9 more
semanticscholar   +1 more source

Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis

open access: yesDrug Design, Development and Therapy, 2022
Background Traditional Chinese medicine (TCM) has the advantage of multi-component and multi-target, which becomes a hot spot in the treatment of numerous diseases.
Jin Wu   +6 more
semanticscholar   +1 more source

The Scientific Competitiveness of Nations [PDF]

open access: yes, 2014
We use citation data of scientific articles produced by individual nations in different scientific domains to determine the structure and efficiency of national research systems.
Cimini, Giulio   +2 more
core   +3 more sources

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