Results 61 to 70 of about 628,285 (376)
The heterogeneous pharmacological medical biochemical network PharMeBINet
Scientific Data, 2022 AbstractHeterogeneous biomedical pharmacological databases are important for multiple fields in bioinformatics. Hetionet is a freely available database combining diverse entities and relationships from 29 public resources. Therefore, it is used as the basis for this project.
Königs, Cassandra +2 more
openaire +3 more sources
Scientific Reports, 2023 Quercetin (QR) has significant anti-respiratory syncytial virus (RSV) effects. However, its therapeutic mechanism has not been thoroughly explored. In this study, a lung inflammatory injury model caused by RSV was established in mice.
Ya-Lei Sun +7 more
doaj +1 more source
A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis [PDF]
Evidence-Based Complementary and Alternative Medicine, 2016 As the most familiar type of arthritis and a chronic illness of the joints, Osteoarthritis (OA) affects a great number of people on the global scale. XuanHuSuo powder (XHSP), a conventional herbal formula from China, has been extensively applied in OA treatment. Nonetheless, its pharmacological mechanism has not been completely expounded.
Huaqi Tang +9 more
openaire +2 more sources
Review of Natural Language Processing in Pharmacology [PDF]
arXiv, 2022 Natural language processing (NLP) is an area of artificial intelligence that applies information technologies to process the human language, understand it to a certain degree, and use it in various applications. This area has rapidly developed in the last few years and now employs modern variants of deep neural networks to extract relevant patterns ...
arxiv
Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]
, 2019 Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J +4 more
core +2 more sources
Systems pharmacology and genome medicine: a future perspective [PDF]
, 2009 Genome medicine uses genomic information in the diagnosis of disease and in prescribing treatment. This transdisciplinary field brings together knowledge on the relationships between genetics, pathophysiology and pharmacology.
Berger, Seth I +2 more
core +2 more sources
FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl +2 more
wiley +1 more source
Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment
Frontiers in Pharmacology, 2019 The research field of systems biology has greatly advanced and, as a result, the concept of network pharmacology has been developed. This advancement, in turn, has shifted the paradigm from a “one-target, one-drug” mode to a “network-target, multiple ...
Runzhi Zhang +3 more
doaj +1 more source
Contrast Media & Molecular Imaging, 2022 Background. As a classic prescription in Chinese medicine treatment, Xiaochaihutang (XCHT) can improve the clinical effect and reduce serum tumor markers in patients with breast cancer (BC). However, there has not been any study to confirm the mechanism. We used bioinformatics analysis and network pharmacology to find the potential targets.
Lin Zheng +5 more
openaire +2 more sources
Pharmacological Effects of Agastache rugosa against Gastritis Using a Network Pharmacology Approach [PDF]
Biomolecules, 2020 Agastache rugosa is used as a Korean traditional medicine to treat gastric diseases. However, the active ingredients and pharmacological targets of A. rugosa are unknown. In this study, we aimed to reveal the pharmacological effects of A. rugosa on gastritis by combining a mice model and a network pharmacology method.
Hyeon-Hwa Nam +8 more
openaire +3 more sources