Results 91 to 100 of about 14,010,421 (310)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Information theory reveals physiological manifestations of COVID-19 that correlate with symptom density of illness

Frontiers in Network Physiology
Algorithms for the detection of COVID-19 illness from wearable sensor devices tend to implicitly treat the disease as causing a stereotyped (and therefore recognizable) deviation from healthy physiology.
Jacob M. Ryan, Shreenithi Navaneethan, Natalie Damaso, Stephan Dilchert, Wendy Hartogensis, Joseph L. Natale, Frederick M. Hecht, Ashley E. Mason, Benjamin L. Smarr, Benjamin L. Smarr   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A statistical analysis method for probability distributions in Erdös–Rényi random networks with preferential cutting–rewiring operation

Frontiers in Network Physiology
The study of specific physiological processes from the perspective of network physiology has gained recent attention. Modeling the global information integration among the separated functionalized modules in structural and functional brain networks is a ...
Yu Qian, Jiahui Cao, Jing Han, Siyi Zhang, Wentao Chen, Zhao Lei, Xiaohua Cui, Zhigang Zheng, Zhigang Zheng, Zhigang Zheng   +9 more
doaj   +1 more source

Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro

Molecular and cellular neurosciences, 2011
Schizophrenia and bipolar disorder are common diseases caused by multiple genes that disrupt brain circuits. While great progress has been made in identifying schizophrenia susceptibility genes, these studies have left two major unanswered mechanistic ...
Erik J Maclaren, P. Charlesworth, M. Coba, S. Grant   +3 more
semanticscholar   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Information dynamics of brain–heart physiological networks during sleep

New Journal of Physics, 2014
This study proposes an integrated approach, framed in the emerging fields of network physiology and information dynamics, for the quantitative analysis of brain–heart interaction networks during sleep. With this approach, the time series of cardiac vagal
L Faes, G Nollo, F Jurysta, D Marinazzo
doaj   +1 more source

Resting-state “Physiological Networks” [PDF]

, 2019
Abstract Slow changes in systemic brain physiology can elicit large fluctuations in fMRI time series, which may manifest as structured spatial patterns of temporal correlations between distant brain regions. These correlations can appear similar to large-scale networks typically attributed to coupled neuronal activity.
Chen, Jingyuan E., Lewis, Laura D., Chang, Catie, Fultz, Nina E., Ohringer, Ned A., Rosen, Bruce R., Polimeni, Jonathan R.   +6 more
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source