Results 71 to 80 of about 14,010,421 (310)

Undiscovered Physiology of Transcript and Protein Networks

Comprehensive Physiology, 2016
ABSTRACT The past two decades have witnessed a rapid evolution in our ability to measure RNA and protein from biological systems. As a result, new principles have arisen regarding how information is processed in cells, how decisions are made, and the role of networks in biology.
Monte, Emma, Rosa-Garrido, Manuel, Vondriska, Thomas, Wang, Jessica   +3 more
openaire   +5 more sources

Physiological Network Is Disrupted in Severe COVID-19

Frontiers in Physiology, 2022
The human body is a complex system maintained in homeostasis thanks to the interactions between multiple physiological regulation systems. When faced with physical or biological perturbations, this system must react by keeping a balance between adaptability and robustness.
Antonio Barajas-Martínez, Antonio Barajas-Martínez, Antonio Barajas-Martínez, Roopa Mehta, Elizabeth Ibarra-Coronado, Ruben Fossion, Ruben Fossion, Vania J. Martínez Garcés, Vania J. Martínez Garcés, Monserrat Ramírez Arellano, Monserrat Ramírez Arellano, Ibar A. González Alvarez, Yamilet Viana Moncada Bautista, Omar Y. Bello-Chavolla, Natalia Ramírez Pedraza, Bethsabel Rodríguez Encinas, Carolina Isabel Pérez Carrión, María Isabel Jasso Ávila, Jorge Carlos Valladares-García, Pablo Esteban Vanegas-Cedillo, Diana Hernández Juárez, Arsenio Vargas-Vázquez, Arsenio Vargas-Vázquez, Neftali Eduardo Antonio-Villa, Neftali Eduardo Antonio-Villa, Paloma Almeda-Valdes, Osbaldo Resendis-Antonio, Osbaldo Resendis-Antonio, Marcia Hiriart, Alejandro Frank, Alejandro Frank, Alejandro Frank, Carlos A. Aguilar-Salinas, Ana Leonor Rivera, Ana Leonor Rivera   +34 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Analysing complex excitation patterns in cardiac tissue using wave event networks

Frontiers in Network Physiology
Cardiac dynamics is governed by complex electrical wave patterns, with disruptions leading to pathological conditions like atrial or ventricular fibrillation.
Hans Friedrich Von Koeller, Hans Friedrich Von Koeller, Alexander Schlemmer, Stefan Luther, Stefan Luther, Stefan Luther, Stefan Luther, Yannic Döring, Yannic Döring, Niels Voigt, Niels Voigt, Niels Voigt, Ulrich Parlitz, Ulrich Parlitz, Ulrich Parlitz   +14 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

On the robustness of the emergent spatiotemporal dynamics in biophysically realistic and phenomenological whole-brain models at multiple network resolutions

Frontiers in Network Physiology
The human brain is a complex dynamical system which displays a wide range of macroscopic and mesoscopic patterns of neural activity, whose mechanistic origin remains poorly understood.
Cristiana Dimulescu, Cristiana Dimulescu, Ronja Strömsdörfer, Ronja Strömsdörfer, Agnes Flöel, Agnes Flöel, Klaus Obermayer, Klaus Obermayer, Klaus Obermayer   +8 more
doaj   +1 more source

Coupled network of the circadian clocks: a driving force of rhythmic physiology

FEBS Letters, 2020
The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt to daily changes in their environment.
Anna-Marie Finger, C. Dibner, A. Kramer
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Catholic Women's Network, July / August, 1996

, 1996
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core   +1 more source