Results 71 to 80 of about 271,086 (294)

Information theory reveals physiological manifestations of COVID-19 that correlate with symptom density of illness

Frontiers in Network Physiology
Algorithms for the detection of COVID-19 illness from wearable sensor devices tend to implicitly treat the disease as causing a stereotyped (and therefore recognizable) deviation from healthy physiology.
Jacob M. Ryan, Shreenithi Navaneethan, Natalie Damaso, Stephan Dilchert, Wendy Hartogensis, Joseph L. Natale, Frederick M. Hecht, Ashley E. Mason, Benjamin L. Smarr, Benjamin L. Smarr   +9 more
doaj   +1 more source

Mitochondrial network responses in oxidative physiology and disease

Free Radical Biology and Medicine, 2018
Mitochondrial activities are linked directly or indirectly to all cellular functions in aerobic eukaryotes. Omics methods enable new approaches to study functional organization of mitochondria and their adaptive and maladaptive network responses to bioenergetic fuels, physiologic demands, environmental challenges and aging.
Go, Young-Mi, Fernandes, Jolyn, Hu, Xin, Uppal, Karan, Jones, Dean P.   +4 more
openaire   +2 more sources

Vascular physiology drives functional brain networks [PDF]

NeuroImage, 2018
ABSTRACT We present the first evidence for vascular regulation driving fMRI signals in specific functional brain networks. Using concurrent neuronal and vascular stimuli, we collected 30 BOLD fMRI datasets in 10 healthy individuals: a working memory task, flashing checkerboard stimulus, and CO 2
Molly G. Bright, Joseph R. Whittaker, Ian D. Driver, Kevin Murphy 0001   +3 more
openaire   +3 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

A statistical analysis method for probability distributions in Erdös–Rényi random networks with preferential cutting–rewiring operation

Frontiers in Network Physiology
The study of specific physiological processes from the perspective of network physiology has gained recent attention. Modeling the global information integration among the separated functionalized modules in structural and functional brain networks is a ...
Yu Qian, Jiahui Cao, Jing Han, Siyi Zhang, Wentao Chen, Zhao Lei, Xiaohua Cui, Zhigang Zheng, Zhigang Zheng, Zhigang Zheng   +9 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Transgelin Induces Dysfunction of Fetal Endothelial Colony-Forming Cells From Gestational Diabetic Pregnancies

, 2018
Fetal exposure to gestational diabetes mellitus (GDM) predisposes children to future health complications including hypertension and cardiovascular disease.
Garretson, Rashell O., Tu, Wanzhu, Chu, Chenghao, Blue, Emily K., Gohn, Cassandra R., Haneline, Laura S., Varberg, Kaela M.   +6 more
core   +1 more source

A physiologically realistic in vitro model of microvascular networks [PDF]

Biomedical Microdevices, 2009
Existing microfluidic devices, e.g. parallel plate flow chambers, do not accurately depict the geometry of microvascular networks in vivo. We have developed a synthetic microvascular network (SMN) on a polydimethalsiloxane (PDMS) chip that can serve as an in vitro model of the bifurcations, tortuosities, and cross-sectional changes found in ...
Jenna M, Rosano, Nazanin, Tousi, Robert C, Scott, Barbara, Krynska, Victor, Rizzo, Balabhaskar, Prabhakarpandian, Kapil, Pant, Shivshankar, Sundaram, Mohammad F, Kiani   +8 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Kinetic analyses of vasculogenesis inform mechanistic studies

, 2017
Vasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell functionality. However, current assays lack
Dunn, Kenneth W., Winfree, Seth, Tu, Wanzhu, Chu, Chenghao, Blue, Emily K., Gohn, Cassandra R., Haneline, Laura S., Varberg, Kaela M.   +7 more
core   +1 more source