Results 51 to 60 of about 14,010,421 (310)

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source

Energy paradox in REM sleep: balancing supply and consumption in brain metabolism

Communications Biology
The brain’s capacity for information processing depends on precisely regulated energy dynamics. Yet how metabolic supply adapts to shifting computational demands across brain states remains unclear.
Yusuke Takahashi, Yoko Ikoma, Ko Matsui
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Parenclitic network mapping predicts survival in critically ill patients with sepsis

Physiological Reports
Sepsis is a complex disease involving multiple organ systems. A network physiology approach to sepsis may reveal collective system behaviors and intrinsic organ interactions.
Emily Ito, Tope Oyelade, Matthew Wikner, Jinyuan Liu, Watjana Lilaonitkul, Ali R. Mani   +5 more
doaj   +1 more source

Diurnal modulation of optogenetically evoked neural signals

Neuroscience Research
Neural signal processing in the cerebral cortex is often regarded as robust and stereotyped; however, the brain’s internal environment undergoes dynamic fluctuations across the day.
Yuki Donen, Yoko Ikoma, Ko Matsui
doaj   +1 more source

Altering physiological networks using drugs: steps towards personalized physiology [PDF]

BMC Medical Genomics, 2013
Abstract Background The rise of personalized medicine has reminded us that each patient must be treated as an individual. One factor in making treatment decisions is the physiological state of each patient, but definitions of relevant states and methods to visualize state-related physiologic changes are scarce.
Grossman, Adam D, Cohen, Mitchell J, Manley, Geoffrey T, Butte, Atul J   +3 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Complexity synchronization analysis of neurophysiological data: Theory and methods

Frontiers in Network Physiology
IntroductionWe present a theoretical foundation based on the spontaneous self-organized temporal criticality (SOTC) and multifractal dimensionality μ to model complex neurophysiological and behavioral systems to infer the optimal empirical transfer of ...
Ioannis Schizas, Sabrina Sullivan, Scott Kerick, Korosh Mahmoodi, J. Cortney Bradford, David L. Boothe, Piotr J. Franaszczuk, Piotr J. Franaszczuk, Paolo Grigolini, Bruce J. West, Bruce J. West   +10 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Co-Community Network Analysis Reveals Alterations in Brain Networks in Alzheimer’s Disease

Brain Sciences
Background: Alzheimer’s disease (AD) is a common neurodegenerative disease. Functional magnetic resonance imaging (fMRI) can be used to measure the temporal correlation of blood-oxygen-level-dependent (BOLD) signals in the brain to assess the brain’s ...
Xiaodong Wang, Zhaokai Zhang, Lingli Deng, Jiyang Dong   +3 more
doaj   +1 more source