Results 51 to 60 of about 271,086 (294)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Magnitude-constrained optimal chaotic desynchronization of neural populations

Frontiers in Network Physiology
In this paper, we calculate magnitude-constrained optimal stimuli for desynchronizing a population of neurons by maximizing the Lyapunov exponent for the phase difference between pairs of neurons while simultaneously minimizing the energy which is used ...
Michael Zimet, Faranak Rajabi, Jeff Moehlis, Jeff Moehlis   +3 more
doaj   +1 more source

Power-law correlations and coupling of active and quiet states underlie a class of complex systems with self-organization at criticality [PDF]

EPJ Web of Conferences, 2020
Physical and biological systems often exhibit intermittent dynamics with bursts or avalanches (active states) characterized by power-law size and duration distributions.
Lombardi Fabrizio, Wang Jilin W.J.L., Zhang Xiyun, Ivanov Plamen Ch   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Analysing complex excitation patterns in cardiac tissue using wave event networks

Frontiers in Network Physiology
Cardiac dynamics is governed by complex electrical wave patterns, with disruptions leading to pathological conditions like atrial or ventricular fibrillation.
Hans Friedrich Von Koeller, Hans Friedrich Von Koeller, Alexander Schlemmer, Stefan Luther, Stefan Luther, Stefan Luther, Stefan Luther, Yannic Döring, Yannic Döring, Niels Voigt, Niels Voigt, Niels Voigt, Ulrich Parlitz, Ulrich Parlitz, Ulrich Parlitz   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

On the robustness of the emergent spatiotemporal dynamics in biophysically realistic and phenomenological whole-brain models at multiple network resolutions

Frontiers in Network Physiology
The human brain is a complex dynamical system which displays a wide range of macroscopic and mesoscopic patterns of neural activity, whose mechanistic origin remains poorly understood.
Cristiana Dimulescu, Cristiana Dimulescu, Ronja Strömsdörfer, Ronja Strömsdörfer, Agnes Flöel, Agnes Flöel, Klaus Obermayer, Klaus Obermayer, Klaus Obermayer   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Altering physiological networks using drugs: steps towards personalized physiology [PDF]

BMC Medical Genomics, 2013
Abstract Background The rise of personalized medicine has reminded us that each patient must be treated as an individual. One factor in making treatment decisions is the physiological state of each patient, but definitions of relevant states and methods to visualize state-related physiologic changes are scarce.
Grossman, Adam D, Cohen, Mitchell J, Manley, Geoffrey T, Butte, Atul J   +3 more
openaire   +4 more sources