Results 61 to 70 of about 271,086 (294)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Undiscovered Physiology of Transcript and Protein Networks

Comprehensive Physiology, 2016
ABSTRACT The past two decades have witnessed a rapid evolution in our ability to measure RNA and protein from biological systems. As a result, new principles have arisen regarding how information is processed in cells, how decisions are made, and the role of networks in biology.
Monte, Emma, Rosa-Garrido, Manuel, Vondriska, Thomas, Wang, Jessica   +3 more
openaire   +5 more sources

Physiological Network Is Disrupted in Severe COVID-19

Frontiers in Physiology, 2022
The human body is a complex system maintained in homeostasis thanks to the interactions between multiple physiological regulation systems. When faced with physical or biological perturbations, this system must react by keeping a balance between adaptability and robustness.
Antonio Barajas-Martínez, Antonio Barajas-Martínez, Antonio Barajas-Martínez, Roopa Mehta, Elizabeth Ibarra-Coronado, Ruben Fossion, Ruben Fossion, Vania J. Martínez Garcés, Vania J. Martínez Garcés, Monserrat Ramírez Arellano, Monserrat Ramírez Arellano, Ibar A. González Alvarez, Yamilet Viana Moncada Bautista, Omar Y. Bello-Chavolla, Natalia Ramírez Pedraza, Bethsabel Rodríguez Encinas, Carolina Isabel Pérez Carrión, María Isabel Jasso Ávila, Jorge Carlos Valladares-García, Pablo Esteban Vanegas-Cedillo, Diana Hernández Juárez, Arsenio Vargas-Vázquez, Arsenio Vargas-Vázquez, Neftali Eduardo Antonio-Villa, Neftali Eduardo Antonio-Villa, Paloma Almeda-Valdes, Osbaldo Resendis-Antonio, Osbaldo Resendis-Antonio, Marcia Hiriart, Alejandro Frank, Alejandro Frank, Alejandro Frank, Carlos A. Aguilar-Salinas, Ana Leonor Rivera, Ana Leonor Rivera   +34 more
openaire   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Network self-organization explains the statistics and dynamics of synaptic connection strengths in cortex [PDF]

, 2013
The information processing abilities of neural circuits arise from their synaptic connection patterns. Understanding the laws governing these connectivity patterns is essential for understanding brain function.
Jochen Triesch (106561), Dimitrakakis, Christos, Pengsheng Zheng, Triesch, J., Jochen Triesch, Christos Dimitrakakis (106559), Zheng, Pengsheng, Zheng, P.,, Zheng, P., Triesch, J.,, Triesch, Jochen, Dimitrakakis, Christos,, Christos Dimitrakakis, Pengsheng Zheng (106555)   +13 more
core   +1 more source

How synaptic function controls critical transitions in spiking neuron networks: insight from a Kuramoto model reduction

Frontiers in Network Physiology
The dynamics of synaptic interactions within spiking neuron networks play a fundamental role in shaping emergent collective behavior. This paper studies a finite-size network of quadratic integrate-and-fire neurons interconnected via a general synaptic ...
Lev A. Smirnov, Vyacheslav O. Munyayev, Maxim I. Bolotov, Grigory V. Osipov, Igor Belykh   +4 more
doaj   +1 more source

Information dynamics of brain–heart physiological networks during sleep

New Journal of Physics, 2014
This study proposes an integrated approach, framed in the emerging fields of network physiology and information dynamics, for the quantitative analysis of brain–heart interaction networks during sleep. With this approach, the time series of cardiac vagal
L Faes, G Nollo, F Jurysta, D Marinazzo
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source