Results 61 to 70 of about 14,010,421 (310)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Assessing the therapeutic potential of vagus nerve stimulation in autoimmune diseases: A systematic review

Physiological Reports
Emerging evidence suggests that the vagus nerve can modulate the immune system in experimental settings. Vagus nerve stimulation (VNS), initially developed for managing epilepsy, is now being explored as a treatment for autoimmune diseases due to its ...
Eubi Chan, Ali R. Mani
doaj   +1 more source

Physiologic Network-Based Brain-Heart Interaction Quantification During Visual Emotional Elicitation

IEEE Transactions on Neural Systems and Rehabilitation Engineering
In recent years, there has been a surge in interest regarding the intricate physiological interplay between the brain and the heart, particularly during emotional processing.
Zhipeng Cai, Hongxiang Gao, Min Wu, Jianqing Li, Chengyu Liu   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Population coding and self-organized ring attractors in recurrent neural networks for continuous variable integration

Frontiers in Network Physiology
Representing and integrating continuous variables is a fundamental capability of the brain, often relying on ring attractor circuits that maintain a persistent bump of activity. To investigate how such structures can self-organize, we trained a recurrent
Roman Kononov, Roman Kononov, Vasilii Tiselko , Vasilii Tiselko , Vasilii Tiselko , Oleg Maslennikov , Oleg Maslennikov , Vladimir Nekorkin , Vladimir Nekorkin    +8 more
doaj   +1 more source

Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer’s disease

Molecular Psychiatry, 2023
Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique morphological and functional properties that allow them to precisely control local circuitry, brain networks and memory processing.
Sara Hijazi, A. B. Smit, R. V. van Kesteren   +2 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Magnitude-constrained optimal chaotic desynchronization of neural populations

Frontiers in Network Physiology
In this paper, we calculate magnitude-constrained optimal stimuli for desynchronizing a population of neurons by maximizing the Lyapunov exponent for the phase difference between pairs of neurons while simultaneously minimizing the energy which is used ...
Michael Zimet, Faranak Rajabi, Jeff Moehlis, Jeff Moehlis   +3 more
doaj   +1 more source

DNA Methylation Reorganization of Skeletal Muscle-Specific Genes in Response to Gestational Obesity

Frontiers in Physiology, 2020
The goals were to investigate in umbilical cord tissue if gestational obesity: (1) was associated with changes in DNA methylation of skeletal muscle-specific genes; (2) could modulate the co-methylation interactions among these genes.
Anna Prats-Puig, Sergi García-Retortillo, Sergi García-Retortillo, Miquel Puig-Parnau, Fidanka Vasileva, Raquel Font-Lladó, Sílvia Xargay-Torrent, Gemma Carreras-Badosa, Berta Mas-Parés, Judit Bassols, Abel López-Bermejo   +10 more
doaj   +1 more source