Results 111 to 120 of about 271,086 (294)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology [PDF]

, 2009
The use of computational modeling and simulation has increased in many biological fields, but despite their potential these techniques are only marginally applied in nutritional sciences.
Ommen, Ben van, De Roos Baukje, Ommen, Ben van,, van Ommen Ben, van Ommen, Ben, Graaf, A.A. de, Martin Adiels, Adiels, Martin,, Rullmann, Johan A.C., Roos, Baukje de, Kevin D. Hall, de Graaf Albert A., Freidig, Andreas P.,, Hall, Kevin D.,, Neema Jamshidi, Andreas P. Freidig, Adiels, M., Hall, Kevin D, Hall Kevin D., Baukje De Roos, Johan A C Rullmann, Rullmann, J.A.C., Ben van Ommen, Graaf, Albert A. de, Rullmann Johan A.C., Freidig, Andreas P, Andreas P Freidig, Jamshidi Neema, Jamsheedi, Neema, Heinemann, M., Heinemann Matthias, Roos, B. de, Johan A.C. Rullmann, Adiels Martin, De Roos, Baukje, Ommen, B. van, Albert A de Graaf, Jamshidi, Neema,, de Graaf, Albert A, Adiels, Martin, Hall, K.D., Freidig, Andreas P., Heinemann, Matthias,, Hall, Kevin D., Roos, Baukje de,, Rullmann, Johan A C, Heinemann, Matthias; id_orcid, Albert A. de Graaf, Freidig Andreas P., Rullmann, Johan AC, Graaf, Albert A. de,, Freidig, A.P., Heinemann, Matthias, Matthias Heinemann, Rullmann, Johan A.C.,, Jamshidi, Neema, Jamshidi, N., Kevin D Hall   +57 more
core   +1 more source

Assessing High-Order Links in Cardiovascular and Respiratory Networks via Static and Dynamic Information Measures

IEEE Open Journal of Engineering in Medicine and Biology
Goal: The network representation is becoming increasingly popular for the description of cardiovascular interactions based on the analysis of multiple simultaneously collected variables.
Gorana Mijatovic, Laura Sparacino, Yuri Antonacci, Michal Javorka, Daniele Marinazzo, Sebastiano Stramaglia, Luca Faes   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Corrigendum: Two-Tiered Response of Cardiorespiratory-Cerebrovascular Network to Orthostatic Challenge

Frontiers in Physiology, 2021
Peter Mukli, Peter Mukli, Peter Mukli, Zoltan Nagy, Frigyes Samuel Racz, Istvan Portoro, Andras Hartmann, Andras Hartmann, Orestis Stylianou, Orestis Stylianou, Robert Debreczeni, Daniel Bereczki, Andras Eke, Andras Eke, Andras Eke   +14 more
doaj   +1 more source

Restoring the complexity of walking in the elderly and its impact on clinical measures around the risk of falls

Frontiers in Network Physiology
Introduction: The hypothesis of the loss of complexity with aging and disease has received strong attention. Especially, the decrease of complexity of stride interval series in older people, during walking, was shown to correlate with falling propensity.
Samar Ezzina, Samar Ezzina, Simon Pla, Didier Delignières   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The International Centre of Insect Physiology and Ecology (ICIPE) as an Integral part of the Agricultural Centres Network: Support Paper to the Application

, 1974
Overview of the objectives and work of the International Centre of Insect Physiology and Ecology (ICIPE) submitted with the application of ICIPE's Governing Board for CGIAR support for consideration at TAC 9, February 1875.The paper presents ICIPE's ...
Odhiambo, Thomas R., International Centre of Insect Physiology and Ecology   +1 more
core  

Editorial: Circadian rhythms of mental health

Frontiers in Network Physiology, 2023
Kneginja Richter, Kneginja Richter, Kneginja Richter, Thomas Penzel   +3 more
doaj   +1 more source

Collective behavior of higher-order globally coupled oscillatory networks in response to positive and negative couplings

Frontiers in Network Physiology
Collective behavior is among the most fascinating complex dynamics in coupled networks with applications in various fields. Recent works have shown that higher-order interactions widely exist in complex systems.
Lixin Yang, Mengjiao Li, Jun Jiang
doaj   +1 more source