Results 41 to 50 of about 112,253 (268)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characteristics of life-cycle carbon dioxide emissions of arterial highway maintenance and the influencing factors

Advances in Climate Change Research
With the focus of highway development transitioning from construction to maintenance, a comprehensive understanding of the characteristics and influencing factors of carbon dioxide (CO2) emissions from highway maintenance activities is crucial for ...
Yao Wang, Yuan-Qing Wang, Shu-Juan Ji, Si-Jia Sun, Shu-Hong Ma, Ya-Nan Gao   +5 more
doaj   +1 more source

Programmable In-Network Obfuscation of Traffic

CoRR, 2020
Recent advances in programmable switch hardware offer a fresh opportunity to protect user privacy. This paper presents PINOT, a lightweight in-network anonymity solution that runs at line rate within the memory and processing constraints of hardware switches. PINOT encrypts a client's IPv4 address with an efficient encryption scheme to hide the address
Liang Wang 0054, Hyojoon Kim, Prateek Mittal, Jennifer Rexford   +3 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

TIME SERIES FORECASTING BY THE ARIMA METHOD

Scientific Journal of Astana IT University, 2022
The variety of communication services and the growing number of different sensors with the appearance of IoT (Internet of Things) technology generate significantly different types of network traffic.
Gulnara Bektemyssova, Abdul Rahim Ahmad, Sharafat Mirzakulova, Zhanar Ibraeva   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Real-Time Intelligent Anomaly Detection and Prevention System

Sakarya University Journal of Computer and Information Sciences, 2023
Real-time anomaly detection in network traffic is a method that detects unexpected and anomalous behaviour by identifying normal behaviour and statistical patterns in network traffic data.
Tuncay Yiğit, Şerafettin Atmaca, Remzi Gürfidan   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

COMPETITIVENESS OF AN ENTERPRISE’S BUSINESS ACTIVITY AND FACTOR DETERMINING IT

Russian Journal of Economics and Law, 2014
Objective: to identify the necessity to introduce the concept of "competitiveness of business activity of an organization" in the services sector, to define the content of this concept and to analyze the main factors contributing to the competitiveness ...
P. I. Kuz’Mina
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source