Results 81 to 90 of about 136,842 (319)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Node-Identification-Based Secure Time Synchronization in Industrial Wireless Sensor Networks

open access: yesSensors, 2018
Time synchronization is critical for wireless sensors networks in industrial automation, e.g., event detection and process control of industrial plants and equipment need a common time reference.
Zhaowei Wang   +4 more
doaj   +1 more source

Intelligent Question Answering in Restricted Domains Using Deep Learning and Question Pair Matching

open access: yesIEEE Access, 2020
With the rapid expansion of the Internet, intelligent question answering for information retrieval has once again gained widespread attention. However, current question answering models mainly focus on the general and common-sense questions in open ...
Lin-Qin Cai   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

A Novel Fault Early Warning Model Based on Fault Gene Table for Smart Distribution Grids

open access: yesEnergies, 2017
Since a smart distribution grid has a diversity of components and complicated topology; it is very hard to achieve fault early warning for each part. A fault early warning model for smart distribution grid combining a back propagation (BP) neural network
Min Xiang   +3 more
doaj   +1 more source

Controllability Transition and Nonlocality in Network Control

open access: yesPhysical Review Letters, 2013
A common goal in the control of a large network is to minimize the number of driver nodes or control inputs. Yet, the physical determination of control signals and the properties of the resulting control trajectories remain widely under-explored. Here we show that: (i) numerical control fails in practice even for linear systems if the controllability ...
Sun, Jie, Motter, Adilson E.
openaire   +4 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

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