Results 51 to 60 of about 6,874,330 (243)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Professional learning and the on-line discussion
Information Research: An International Electronic Journal, 1997 This paper explores the growing interest in professional development through asynchronous electronic discussion. It presents an excerpt from within a recent forum on telematic learning and analyses ways of initiating discussion; styles of messages and ...
Michael Hammond
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Information Research: An International Electronic Journal, 1997 Educationalists worldwide are seeking to adopt on-line systems to improve their course presentations. This raises a number of issues, about how these on-line systems can best be integrated and also what structures and resources need to be put in place to
Tina Wilson, Denise Whitelock
doaj
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Using a NLSI to deliver the Effective Learning Programme: problems and practicalities
Information Research: An International Electronic Journal, 1997 In 1996 the University of Lincolnshire and Humberside implemented its Effective Learning programme (ELP). This is delivered by a Networked Learning Support Intranet (NLSI).
Bob Hunter
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Large-scale computer-mediated training for management teachers
Information Research: An International Electronic Journal, 1997 In 1995/6 the Open University Business School (OUBS) trained 187 tutors in the UK and Continental Western Europe in Computer Mediated Conferencing (CMC) for management education. The medium chosen for the training was FirstClassTM.
Gilly Salmon, Ken Giles, John Allen
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The RUNES middleware: a reconfigurable component-based approach to networked embedded systems [PDF]
, 2005 In this paper the RUNES approach to the development of software for networked embedded systems is described. There is a need for a program platform with abstractions that are able to span the full range of heterogeneous embedded systems, and which also ...
Picco, G.P. +15 more
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