Results 111 to 120 of about 1,139,490 (222)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Back Matter - JTSiskom Volume 5 Nomor 1 Tahun 2017
Jurnal Teknologi dan Sistem Komputer, 2017 Artikel ini berisi back-matter JTSiskom Volume 5 Nomor 1 Tahun 2017, yaitu meliputi indeks penulis, petunjuk penulisan dan kirim artikel JTSiskom, perjanjian pengalihan hak cipta, form pengalihan hak cipta, pernyataan etika publikasi dan lisensi isi ...
Ketua Editor JTSiskom
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Social Networking Websites and Teens [PDF]
, 2007 Presents findings from a survey that examines how Americans ages 12-17 use online networking to make new friends and maintain existing personal relationships.
Amanda Lenhart, Mary Madden
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Networks, NetWorks, NETWorks, NETWORKS
, 1997 Business networks are having different characteristics and building blocs when looked upon from diverse perspectives. In this paper the aim is to highlight some aspects of the multi-facetted nature of business networks in marketing between industrial companies especially. A model is used as a base for discussing different networks in business settings.
openaire +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The networking effects of OER [PDF]
, 2009 Open Educational Resources (OER) give an openly available set of content and tools that in principle provide a basis for formal and informal communication and collaboration between groups of individuals around teaching and/or learning.
Lane, Andrew +2 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Towards goal-based autonomic networking [PDF]
, 2009 The ability to quickly deploy and efficiently manage services is critical to the telecommunications industry. Currently, services are designed and managed by different teams with expertise over a wide range of concerns, from high-level business to low ...
Berglund, Åsa +5 more
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