Results 191 to 200 of about 392,800 (301)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Fragment Ion Abundance-Based Molecular Networking (FIAMN) Enables Skeleton-Oriented Discovery of Diterpenoids from a Soft Coral. [PDF]

JACS Au
Gao Z, Wu MJ, Zhang XY, Tang BX, Yao LG, Li J, Zang Y, He M, Guo YW, Li XW.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

ASPIS Academy: A blueprint for building early-career researcher networks to advance NAM-based risk assessment. [PDF]

NAM J
Ladeira L, Martinez R, Hayot G, Islam B, Veltman CHJ, Sanz-Serrano J, Khalidi H, Ortega-Vallbona R, Corradi M, Cöllen E, Steinbach AM, Gabrišová K, Pôbiš P, Barnes D, Glasgow S, Niemeijer M, Zajac JD, Ormanin-Lewandowska A, Moné MJ, van de Water B, Colbourne JK, Vinken M, Tangianu S, Kandarova H, Pallocca G, Busquet F, Kuchovska E.   +26 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Association Between Social Networking Service Use at Age 76 and Six-Year Frailty Trajectories in Community-Dwelling Older Adults. [PDF]

Med Sci (Basel)
Imai N, Homma D, Yoda T, Horigome Y, Murakami R, Fujii T, Kawashima H.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Corrigendum to "The interplay between sleep and cancer-related fatigue in breast cancer: A casual and computer-simulated network analysis" [Asia Pac J Oncol Nurs 12 (2025) 100692]. [PDF]

Asia Pac J Oncol Nurs
Li H, Xiong Y, Zhang Q, Lu Y, Chen Q, Wu S, Deng Y, Yang C, Knobf MT, Ye Z.   +9 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source