Results 181 to 190 of about 16,068 (197)

The Microbial Pathology of Neu5Ac and Gal Epitopes

Journal of Carbohydrate Chemistry, 2013
Glycans play a vital role in modulating many physiological and pathological phenomena of microbes and humans, such as bacterial adhesion, colonization, host-microbial interactions, cancer recognition, and blood group determination. The aim of the current review is to provide an account of the functions of N-acetyl sialic acid (Neu5Ac) and galactose ...
Muhammad Ramzan Manwar Hussain, Hani Asfour, Muhammad Yasir, Asifullah Khan, Hussein Sheikh Ali Mohamoud, Jumana Y. Al-Aama   +5 more
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A convenient synthesis of nucleoside monophosphate-N-acetylneuraminic acids (NMP-Neu5AC)

Bioorganic & Medicinal Chemistry, 1994
Reaction of sialyl phosphites 2a,b with acetyl-protected ribonucleoside monophosphates 3C, 3U, 3A and 3G furnished without addition of a catalyst directly the corresponding beta-configurated sialyl ribonucleoside monophosphates 4C, 4U, 4A and 4G, respectively.
T J, Martin, H, Braun, R R, Schmidt
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Model-based Optimization of Neu5Ac Synthesis

2023
Sialic acids (SAs) are a group of more than 50 structurally distinct α-keto acids found in viruses, mammalian cells, and microorganisms1. They control various biological functions such as development, recognition, cell signaling, cell-cell interactions, and adhesion2. Sialylation of neural cell adhesion molecules during embryonic development is crucial
Çakar, Mehmet Mervan, Findrik Blažević, Zvjezdana   +1 more
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An investigation into Neu5Ac aldolase and KDN-cleaving sialidase

2021
The author retains copyright of this thesis. It must only be used for personal non-commercial research, education and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission. For further terms on this licence: https://rightsstatements.org/page/InC-EDU/1.0/?language=en Contact ...
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Chemical synthesis of cytidine-5′-monophosphono-N-acetylneuraminic acid (CMP-neu5ac)

Tetrahedron Letters, 1993
Abstract CMP-Neu5AC was synthesized for the time from the cytidine 5′-phosphoramidite and the Neu5Ac derivative bearing allyl and allyloxycarbonyl groups as the protecting groups.
Shingo Makino, Yoshihito Ueno, Masahide Ishikawa, Yoshihiro Hayakawa, Tsujiaki Hata   +4 more
openaire   +1 more source

The synthesis of sialylated oligosaccharides using a CMP-Neu5Ac synthetase/sialyltransferase fusion

Nature Biotechnology, 1998
Large-scale enzymatic synthesis of oligosaccharides, which contain terminal N-acetyl-neuraminic acid residues requires large amounts of the sialyltransferase and the corresponding sugar-nucleotide synthetase, which is required for the synthesis of the sugar-nucleotide donor, CMP-Neu5Ac.
M, Gilbert, R, Bayer, A M, Cunningham, S, DeFrees, Y, Gao, D C, Watson, N M, Young, W W, Wakarchuk   +7 more
openaire   +2 more sources

Accumulation of free Neu5Ac-containing complex-type N-glycans in human pancreatic cancers

Glycoconjugate Journal, 2012
We have analyzed the structures of glycosphingolipids and intracellular free glycans in human cancers. In our previous study, trace amounts of free N-acetylneuraminic acid (Neu5Ac)-containing complex-type N-glycans with a single GlcNAc at each reducing terminus (Gn1 type) was found to accumulate intracellularly in colorectal cancers, but were ...
Masahiko, Yabu, Hiroaki, Korekane, Hidenori, Takahashi, Hiroaki, Ohigashi, Osamu, Ishikawa, Yasuhide, Miyamoto   +5 more
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Purification and partial characterization of CMP-Neu5Ac synthetase from rat brain

Analytica Chimica Acta, 2006
Abstract N -Acetyl-neuraminic acid cytidylyltransferase (EC 2.7.7.43) (CMP-Neu5Ac synthetase), which catalyzes the formation of cytidine-5′-monophospho- N -acetyl-neuraminic acid (CMP-Neu5Ac) from cytidine-5′-triphosphate (CTP) and N -acetyl-neuraminic acid (Neu5Ac), was purified from rat brains aged 8–9 days, which presented the highest specific ...
J.C. Feo-Manga, L.B. Rodríguez-Aparicio, M.A. Ferrero, A. Reglero   +3 more
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ChemInform Abstract: Synthesis of Phosphonic Acid Analogues of Sialic Acid Neu5Ac.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T.‐H. CHAN, Y.‐C. XIN
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[Synthesis of Neu5Ac(alpha2-->6)[Gal(alpha1-->3)]GalNAcalpha and Neu5Ac(alpha2-->6)[Gal(beta1-->3)]GalNAcalpha trisaccharides as protected trifluoroacetamidopropyl glycosides].

Bioorganicheskaia khimiia, 1999
Protected sialo-containing trisaccharides, fragments of oligosaccharide chains of mucin glycoproteins, were synthesized. Regioselective sialylation of the primary hydroxyl group of (3-fluoroacetamidopropyl)-2-azido-2-deoxy-3-O-(2,3,4,6-tetra-O-ben zyl)-alpha -D-galactopyranosyl)-alpha-D-galactopyranoside with methyl ester of peracetyl-beta ...
L A, Simeoni, N E, Baĭramova, N V, Bovin   +2 more
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