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Phylogeny of a neural cell adhesion molecule
Developmental Biology, 1985The phylogeny of adhesion among cells derived from neural tissue has been examined using a combination of functional and immunological analyses. The presence of the neural cell adhesion molecule (NCAM) was evaluated with respect to NCAM-specific antigenic determinants attached to a polypeptide chain with appropriate electrophoretic properties. By these
Urs Rutishauser, Alison K. Hall
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Neural Cell Adhesion Molecule of Taste Buds
Journal of Electron Microscopy, 1992The distribution of the neural cell adhesion molecule (N-CAM) in the taste buds of adult and developing mice was studied by use of an immunocytochemical technique. In adult mice, nerve fibers and some elongated taste bud cells reacted with anti-N-CAM antibody.
Yasuko Nagai +3 more
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Targeting the neural cell adhesion molecule in cancer
Cancer Letters, 2007NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies.
Markus Jensen, Frank Berthold
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The neural cell adhesion molecule and synaptic plasticity
Journal of Neurobiology, 1995AbstractHighly stereotyped patterns of neuronal connections are laid down during the development of the nervous system via a range of activity independent and activity dependent mechanisms. Whereas the coarse hard‐wiring of the nervous system appears to rely on molecular recognition events between the neuron, its pathway, and its target, the ...
Mohammed S. Fazeli +2 more
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Developmental biology of a neural cell adhesion molecule [PDF]
Nature, 1984 A membrane glycoprotein isolated from embryonic brain has been shown to be a ligand in the formation of cell-cell bonds. The molecule, called neural cell adhesion molecule (N-CAM), participates in several aspects of neural development, including the formation of plexiform layers, neurite fasciculation and nerve-muscle interactions.
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A Collagen-Binding Mimetic of Neural Cell Adhesion Molecule [PDF]
Bioconjugate Chemistry, 2008 A chimeric protein consisting of a cell-adhesive peptide derived from a neural cell adhesion molecule and a collagen-binding domain was synthesized using recombinant DNA technology. Here, we demonstrate that the chimeric protein binds to type I collagen and promotes the adhesion and neurite extension of hippocampus neurons.
Miyazaki, Hiroko +3 more
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Heterogeneity of Soluble Neural Cell Adhesion Molecule
Journal of Neurochemistry, 1989Abstract: Soluble neural cell adhesion molecule (NCAM) from rat brain neuronal cell culture media consists predominantly of a polypeptide of Mr∼ 115,000. Minor amounts of a polypeptide of Mr∼ 180,000 and two inconsistently appearing components of Mr 160,000 and 145,000 are also observed.
Ole Nybroe +2 more
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Cell Adhesion Molecules in Neural Development (Part 1 of 2)
Developmental Neuroscience, 1989Adhesive mechanisms have been implicated in several morphogenetic processes during development. In the last decade several molecules mediating specific adhesion between cells and between cells and their environment have been characterized. Possible roles in morphogenesis have been established for some of these molecules.
Elisabeth Bock, Dorte Linnemann
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