Results 311 to 320 of about 131,590 (354)

Cell Adhesion Molecules in Neural Histogenesis

Annual Review of Physiology, 1986
Aside from evolutionary change itself, there are three main sources of variabil­ ity in neural networks: the somatic developmental sequence, which is responsi­ ble for network formation and neuroanatomy; the chemical and structural variation at synapses (particularly that related to neurotransmitters and chan­ nels); and the electrical variation that ...
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Intracellular signaling by the neural cell adhesion molecule.

Neurochemical research, 2003
Cell adhesion molecules are known to play far more complex roles than mechanically attaching one cell to an adjacent cell or to components of the extracellular matrix. Thus, important roles for cell adhesion molecules in the regulation of intracellular signaling pathways have been revealed.
Povlsen, Gro K., Ditlevsen, Dorte Kornerup, Berezin, Vladimir, Bock, Elisabeth   +3 more
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The Mechanism of Binding of Neural Cell Adhesion Molecules

1984
The experimental results reviewed in this paper strongly suggest that the molecular mechanism of N-CAM-mediated cell adhesion involves the direct interaction of N-CAM molecules on one cell with N-CAM molecules on a second cell. The rate of this aggregation has a high-order dependence on the local N-CAM concentration, and is inversely related to the ...
Gerald M. Edelman, Stanley Hoffman
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The role of neural cell adhesion molecules in plasticity and repair

Brain Research Reviews, 2001
Repair and functional recovery after brain injury critically depends on structural and functional plasticity of preserved neuronal networks. A striking feature of brain structures where tissue reorganization and plasticity occur is a strong expression of the polysialylated neural cell adhesion molecule (PSA-NCAM).
Kiss, Jozsef Zoltan, Troncoso, Edgardo, Djebbara, Z., Vutskits, Laszlo, Muller, Dominique   +4 more
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The neural cell adhesion molecule.

Current opinion in drug discovery & development, 2009
During the past year, the understanding of the structure and function of neural cell adhesion has advanced considerably. The three-dimensional structures of several of the individual modules of the neural cell adhesion molecule (NCAM) have been determined, as well as the structure of the complex between two identical fragments of the NCAM.
Berezin, V, Bock, E, Poulsen, F M
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Neural GPI anchored cell adhesion molecules

Frontiers in Bioscience, 2003
When first identified, neural cell adhesion molecules (neural CAMs) were thought to act simply by providing cell surfaces with differential adhesion properties. In the decades following the identification of the first neural CAMs, it has been realized that these proteins are actually involved in very complex processes such as axon guidance, neuronal ...
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Expression of Neural Cell Adhesion Molecule in Pancreatic Cancer

Pancreas, 2001
Neural cell adhesion molecule (NCAM) has been found to be a significant factor for survival in various solid tumors. In the present study, we examined the expression of NCAM in exocrine tumors of the pancreas by immunohistochemistry, using two monoclonal antibodies against NCAM and polysialic acid (MAB735).
Shin Takeda, Ekmel Tezel, Akimasa Nakao, Kenji Oshima, Yoshihisa Kawase   +4 more
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Brain Plasticity and the Neural Cell Adhesion Molecule (NCAM)

1997
NCAM is a member of the Ig superfamily that is highly expressed in the nervous system. NCAM mediates cell-cell adhesion and adhesion of cells to the extracellular matrix. In addition to influencing the adhesive behaviour of cells, NCAM binding triggers the activation of intracellular signalling pathways.
Rønn, Lars Christian Biilman, Pedersen, N., Jahnsen, H., Berezin, Vladimir, Bock, Elisabeth   +4 more
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A Developmental Study of the Biosynthesis of the Neural Cell Adhesion Molecule

Developmental Neuroscience, 1985
The neural cell adhesion molecule (N-CAM) is a glycoprotein found in neurons, glial cells and muscle cells. In this report we describe developmental changes in biosynthesis of N-CAM polypeptides in rat forebrain explant cultures. N-CAM was synthesized as the following polypeptides: HMr (Mr between 250,000 and 350,000), A (200,000 Mr), B (135,000 Mr ...
Joan M. Lyles, Elisabeth Bock, Dorte Linnemann   +2 more
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Neural cell adhesion molecules in brain plasticity and disease

Multiple Sclerosis and Related Disorders, 2013
Neural cell adhesion molecule (NCAM) has been studied extensively. But it is only in recent times that interest in this molecule has shifted to conditions such as Alzheimer's disease, Multiple Sclerosis and Schizophrenia, focusing on its role in neurodegeneration and abnormal neurodevelopment.
Gavin Giovannoni, Sharmilee Gnanapavan
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