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Heterogeneity of Soluble Neural Cell Adhesion Molecule
Journal of Neurochemistry, 1989Abstract: Soluble neural cell adhesion molecule (NCAM) from rat brain neuronal cell culture media consists predominantly of a polypeptide of Mr∼ 115,000. Minor amounts of a polypeptide of Mr∼ 180,000 and two inconsistently appearing components of Mr 160,000 and 145,000 are also observed.
Ole Nybroe +2 more
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Differentiation; research in biological diversity, 1985
The expression of the neural cell adhesion molecules L1 and N-CAM and of their shared carbohydrate epitope L2/HNK-1 was studied during the development and after the transection of mouse sciatic nerves.
Joachim Nieke, Melitta Scbachner
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The expression of the neural cell adhesion molecules L1 and N-CAM and of their shared carbohydrate epitope L2/HNK-1 was studied during the development and after the transection of mouse sciatic nerves.
Joachim Nieke, Melitta Scbachner
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Cell Adhesion Molecules in Neural Development (Part 1 of 2)
Developmental Neuroscience, 1989Adhesive mechanisms have been implicated in several morphogenetic processes during development. In the last decade several molecules mediating specific adhesion between cells and between cells and their environment have been characterized. Possible roles in morphogenesis have been established for some of these molecules.
Elisabeth Bock, Dorte Linnemann
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Cell Adhesion Molecules in Neural Histogenesis
Annual Review of Physiology, 1986Aside from evolutionary change itself, there are three main sources of variabil ity in neural networks: the somatic developmental sequence, which is responsi ble for network formation and neuroanatomy; the chemical and structural variation at synapses (particularly that related to neurotransmitters and chan nels); and the electrical variation that ...
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Intracellular signaling by the neural cell adhesion molecule.
Neurochemical research, 2003Cell adhesion molecules are known to play far more complex roles than mechanically attaching one cell to an adjacent cell or to components of the extracellular matrix. Thus, important roles for cell adhesion molecules in the regulation of intracellular signaling pathways have been revealed.
Povlsen, Gro K. +3 more
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Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors.
American Journal of Surgical Pathology, 1998Neural cell adhesion molecules (NCAM) represent specific markers of neuroendocrine (NE) differentiation in lung cancer. Because the polysialic acid form (NCAM-PSA) has reduced adhesion properties, we hypothesized that NCAM-PSA expression could favor ...
S. Lantuejoul +4 more
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The Mechanism of Binding of Neural Cell Adhesion Molecules
1984The experimental results reviewed in this paper strongly suggest that the molecular mechanism of N-CAM-mediated cell adhesion involves the direct interaction of N-CAM molecules on one cell with N-CAM molecules on a second cell. The rate of this aggregation has a high-order dependence on the local N-CAM concentration, and is inversely related to the ...
Gerald M. Edelman, Stanley Hoffman
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The role of neural cell adhesion molecules in plasticity and repair
Brain Research Reviews, 2001Repair and functional recovery after brain injury critically depends on structural and functional plasticity of preserved neuronal networks. A striking feature of brain structures where tissue reorganization and plasticity occur is a strong expression of the polysialylated neural cell adhesion molecule (PSA-NCAM).
Kiss, Jozsef Zoltan +4 more
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The neural cell adhesion molecule.
Current opinion in drug discovery & development, 2009During the past year, the understanding of the structure and function of neural cell adhesion has advanced considerably. The three-dimensional structures of several of the individual modules of the neural cell adhesion molecule (NCAM) have been determined, as well as the structure of the complex between two identical fragments of the NCAM.
Berezin, V, Bock, E, Poulsen, F M
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Neural GPI anchored cell adhesion molecules
Frontiers in Bioscience, 2003When first identified, neural cell adhesion molecules (neural CAMs) were thought to act simply by providing cell surfaces with differential adhesion properties. In the decades following the identification of the first neural CAMs, it has been realized that these proteins are actually involved in very complex processes such as axon guidance, neuronal ...
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