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Targeting the neural cell adhesion molecule in cancer
Cancer Letters, 2007NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies.
Markus, Jensen, Frank, Berthold
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Intracellular Signaling by the Neural Cell Adhesion Molecule
Neurochemical Research, 2003Cell adhesion molecules are known to play far more complex roles than mechanically attaching one cell to an adjacent cell or to components of the extracellular matrix. Thus, important roles for cell adhesion molecules in the regulation of intracellular signaling pathways have been revealed.
Povlsen, Gro K. +3 more
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The neural cell adhesion molecule and synaptic plasticity
Journal of Neurobiology, 1995AbstractHighly stereotyped patterns of neuronal connections are laid down during the development of the nervous system via a range of activity independent and activity dependent mechanisms. Whereas the coarse hard‐wiring of the nervous system appears to rely on molecular recognition events between the neuron, its pathway, and its target, the ...
P, Doherty, M S, Fazeli, F S, Walsh
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Neural cell adhesion molecule expression in thyroid cancer
Oncology Reports, 1996Neural cell adhesion molecule (NCAM) is an integral membrane glycoprotein that participates in cell-cell interactions. We examined the expression of neural cell adhesion molecule (NCAM) by immunohistochemistry in 65 cases of thyroid disease. In the majority of thyroid tumors, NCAM expression was detected in tumor cells.
Y, Miyajima +6 more
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Polysialic acid masks neural cell adhesion molecule antigenicity
Brain Research, 2019The neural cell adhesion molecule (NCAM) is a transmembrane protein involved in major cellular processes. The addition of polysialic acid (PSA), a post-translational modification (PTM) almost exclusively carried by NCAM, alters NCAM properties and functions and is therefore tightly regulated.
Natacha Coppieters +4 more
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Neural cell adhesion molecule expression in Xenopus embryos
Developmental Biology, 1987The spatiotemporal pattern of expression of the neural cell adhesion molecule NCAM was mapped immunohistochemically in embryos of the frog Xenopus, from blastula to early swimming stages, using a polyclonal antibody that recognizes Xenopus NCAM. The neural plate stage was the earliest at which NCAM could be detected.
K, Balak +3 more
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The neural cell adhesion molecule.
Current opinion in drug discovery & development, 2009During the past year, the understanding of the structure and function of neural cell adhesion has advanced considerably. The three-dimensional structures of several of the individual modules of the neural cell adhesion molecule (NCAM) have been determined, as well as the structure of the complex between two identical fragments of the NCAM.
Berezin, V, Bock, E, Poulsen, F M
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Embryonic neural cell adhesion molecules on human natural killer cells
European Journal of Immunology, 1989AbstractThe neural cell adhesion molecules (NCAM) are surface glycoproteins that were first described in brain tissue. NCAM mediate adhesion in a variety of cell‐cell interactions. In the present study we show that the so‐called “embryonic” NCAM, i.e., the highly polysialylated forms of these proteins, are expressed on natural killer cells and some CD3+
M, Husmann +4 more
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Regulation of neural cell adhesion molecule sialylation state
International Journal of Biochemistry, 1991The neural cell adhesion molecule (NCAM) is a complex of three immunologically-related membrane polypeptides of 180, 140 and 120 kDa molecular weight (Hirn et al., 1983; Choung and Edelman, 1984; Sheehan et al., 1986). These isoforms are primary translation products which arise through the alternate splicing of a single gene located on human chromosome
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Cell adhesion molecules in neural development.
Developmental neuroscience, 1989Adhesive mechanisms have been implicated in several morphogenetic processes during development. In the last decade several molecules mediating specific adhesion between cells and between cells and their environment have been characterized. Possible roles in morphogenesis have been established for some of these molecules.
D, Linnemann, E, Bock
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