Results 351 to 360 of about 251,945 (399)
Some of the next articles are maybe not open access.
Expression of Neural Cell Adhesion Molecule in Pancreatic Cancer
Pancreas, 2001Neural cell adhesion molecule (NCAM) has been found to be a significant factor for survival in various solid tumors. In the present study, we examined the expression of NCAM in exocrine tumors of the pancreas by immunohistochemistry, using two monoclonal antibodies against NCAM and polysialic acid (MAB735).
Shin Takeda +4 more
openaire +3 more sources
Brain Plasticity and the Neural Cell Adhesion Molecule (NCAM)
1997NCAM is a member of the Ig superfamily that is highly expressed in the nervous system. NCAM mediates cell-cell adhesion and adhesion of cells to the extracellular matrix. In addition to influencing the adhesive behaviour of cells, NCAM binding triggers the activation of intracellular signalling pathways.
Rønn, Lars Christian Biilman +4 more
openaire +3 more sources
A Developmental Study of the Biosynthesis of the Neural Cell Adhesion Molecule
Developmental Neuroscience, 1985The neural cell adhesion molecule (N-CAM) is a glycoprotein found in neurons, glial cells and muscle cells. In this report we describe developmental changes in biosynthesis of N-CAM polypeptides in rat forebrain explant cultures. N-CAM was synthesized as the following polypeptides: HMr (Mr between 250,000 and 350,000), A (200,000 Mr), B (135,000 Mr ...
Joan M. Lyles +2 more
openaire +3 more sources
Neural cell adhesion molecules in brain plasticity and disease
Multiple Sclerosis and Related Disorders, 2013Neural cell adhesion molecule (NCAM) has been studied extensively. But it is only in recent times that interest in this molecule has shifted to conditions such as Alzheimer's disease, Multiple Sclerosis and Schizophrenia, focusing on its role in neurodegeneration and abnormal neurodevelopment.
Gavin Giovannoni, Sharmilee Gnanapavan
openaire +3 more sources
Neural cell adhesion molecule expression in thyroid cancer
Oncology Reports, 1996Neural cell adhesion molecule (NCAM) is an integral membrane glycoprotein that participates in cell-cell interactions. We examined the expression of neural cell adhesion molecule (NCAM) by immunohistochemistry in 65 cases of thyroid disease. In the majority of thyroid tumors, NCAM expression was detected in tumor cells.
Minoru Hirano +6 more
openaire +3 more sources
The neural cell adhesion molecule NCAM in multiple myeloma
Leukemia & Lymphoma, 1996The Neural Cell Adhesion Molecule NCAM is a membrane glycoprotein and belongs to the immunoglobulin superfamily. It is expressed on neural cells as well as on various neuroendocrine tumors and can be detected in sera of patients with small cell lung cancer. Its role is attributed to tumor invasion and formation of metastases. Malignant plasma cells and
Marcus Oldenburg +2 more
openaire +3 more sources
Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders
European Journal of Pharmacology, 2000Cell adhesion molecule proteins play a diverse role in neural development, signal transduction, structural linkages to extracellular and intracellular proteins, synaptic stabilization, neurogenesis, and learning. Three basic mRNA isoforms and potent posttranslational modifications differentially regulate these neurobiological properties of the neural ...
openaire +3 more sources
Gene regulation of cell adhesion molecules in neural morphogenesis
Acta Paediatrica, 1997A mounting body of evidence suggests that cell‐cell adhesion molecules (CAMs) play critical roles in morphogenetic patterning and in laying down the initial tissue scaffold of the nervous system. Perturbations of CAM binding can lead to altered tissue pattern and interruption of tissue interactions to altered patterns of CAM expression.
Gerald M. Edelman, Frederick S. Jones
openaire +3 more sources
The neural cell adhesion molecule in synaptic plasticity and ageing
International Journal of Developmental Neuroscience, 2000AbstractBy mediating cell adhesion and signal transduction, the neural cell adhesion molecule (NCAM) regulates neurite outgrowth, fasciculation and target recognition in the developing nervous system. In addition, a number of studies suggest an important role for the NCAM in regeneration and learning in the adult nervous system. NCAM‐deficient mice are
Lars Christian B. Rønn +2 more
openaire +2 more sources
Neural cell adhesion molecule expression in Xenopus embryos
Developmental Biology, 1987The spatiotemporal pattern of expression of the neural cell adhesion molecule NCAM was mapped immunohistochemically in embryos of the frog Xenopus, from blastula to early swimming stages, using a polyclonal antibody that recognizes Xenopus NCAM. The neural plate stage was the earliest at which NCAM could be detected.
Marcus Jacobson +3 more
openaire +3 more sources