Results 81 to 90 of about 267,750 (401)

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [PDF]

, 2009
The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT).
Akitaya, Alkhateeb, Andersson, Barrallo-Gimeno, Bertocchini, Chea, Ciruna, del Barrio, Dixon, Dottori, el Ghouzzi, Favier, Gans, Garcia-Castro, Giehl, Haraguchi, Hervé Acloque, Iwano, Johansson, Kalluri, Katherine Fishwick, Kitajima, Kos, Kwok, Liu, Liu, M. Angela Nieto, Manzanares, Marianne Bronner-Fraser, Martin, Mathieu, Meghan S. Adams, Moreno-Bueno, Nakagawa, Nakaya, Nieto, Peinado, Perea-Gomez, Perez-Pomares, Pijnenborg, Popperl, Sato, Sela-Donenfeld, Sela-Donenfeld, Selleck, Shah, Skromne, Tanimizu, Thiery, Varlet   +49 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn’s DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: The presence of myenteric plexitis in the proximal resection margins is a predictive factor of early postoperative recurrence in Crohn’s disease.
Julie Pabois, Tony Durand, Catherine Le Berre, Rhiannon T. Filippone, Théo Noël, Emilie Durieu, Céline Bossard, Sarah Bruneau, Malvyne Rolli-Derkinderen, Kulmira Nurgali, Michel Neunlist, Arnaud Bourreille, Isabelle Neveu, Philippe Naveilhan   +13 more
doaj   +1 more source

TiO2 surfaces support neuron growth during electric field stimulation [PDF]

, 2017
The authors are grateful to Francisco Almendros and Ismael Santamaría for help in preparation of the TiO2 substrates. We acknowledge the European Project NERBIOS (NEST/STREP (FP6), 028473-2) for financial support. Maria Canillas acknowledges the JAE-CSIC
Canillas, M, Chinnaro, E, Moreno, B, Rajnicek, A M   +3 more
core   +1 more source

Functional characterization of chondroitin sulfate proteoglycans of brain: interactions with neurons and neural cell adhesion molecules

Journal of Cell Biology, 1993
Ng-CAM and N-CAM are cell adhesion molecules (CAMs), and each CAM can bind homophilically as demonstrated by the ability of CAM-coated beads (Covaspheres) to self-aggregate.
M. Grumet, Andrea Flaccus, Richard U. Margolis   +2 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity

Frontiers in Molecular Neuroscience, 2018
During neocortical development, newborn neurons migrate along radial fibers from the germinal ventricular zone (VZ) toward the cortical plate (CP) to populate the cerebral cortex.
Yi-An Chen, I-Ling Lu, Jin-Wu Tsai, Jin-Wu Tsai, Jin-Wu Tsai   +4 more
doaj   +1 more source

Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration. [PDF]

PLoS Biology, 2014
Cell migration requires dynamic regulation of cell-cell signaling and cell adhesion. Both of these processes involve endocytosis, lysosomal degradation, and recycling of ligand-receptor complexes and cell adhesion molecules from the plasma membrane ...
Adam M Tuttle, Trevor L Hoffman, Thomas F Schilling   +2 more
doaj   +1 more source

The novel carbohydrate epitope L3 is shared by some neural cell adhesion molecules

Journal of Cell Biology, 1987
The monoclonal L3 antibody reacts with an N-glycosidically linked carbohydrate structure on at least nine glycoproteins of adult mouse brain. Three out of the L3 epitope-carrying glycoproteins could be identified as the neural cell adhesion molecules L1 ...
A. Kücherer, A. Faissner, M. Schachner
semanticscholar   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source