Results 51 to 60 of about 446,619 (318)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Suppression and facilitation of human neural responses

eLife, 2018
Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different ...
Michael-Paul Schallmo, Alexander M Kale, Rachel Millin, Anastasia V Flevaris, Zoran Brkanac, Richard AE Edden, Raphael A Bernier, Scott O Murray   +7 more
doaj   +1 more source

ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex.

PLoS Biology, 2022
Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear.
Claudia I Semprich, Lindsay Davidson, Adriana Amorim Torres, Harshil Patel, James Briscoe, Vicki Metzis, Kate G Storey   +6 more
doaj   +1 more source

Gain control with A-type potassium current: IA as a switch between divisive and subtractive inhibition [PDF]

, 2018
Neurons process information by transforming barrages of synaptic inputs into spiking activity. Synaptic inhibition suppresses the output firing activity of a neuron, and is commonly classified as having a subtractive or divisive effect on a neuron's output firing activity.
arxiv   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Neural Inhibition in a Bird : Effect of Strychnine and Picrotoxin

Nature, 1963
SEVERAL convulsant drugs have been shown to act by impairing specific inhibitory processes in the brain, and there is a clear-cut contrast between crustacean and mammal in this respect. In the crayfish, picrotoxin produces convulsions and it blocks several inhibitory mechanisms as well as the inhibitory action which Florey's Factor I exerts on these ...
Desmedt, Jean Edouard, Delwaide, J.
openaire   +4 more sources

Research on Lateral Inhibition Network Based on Cell Membrane Electrical Model

Photonics
Lateral inhibition is a prevalent occurrence within the biological neural system, enhancing the human brain’s ability to perceive edge information within a given scene.
Dao-Han Qi, Ming-Jie Sun, Qing-Zhong Cai
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

PTEN inhibition and axon regeneration and neural repair

Neural Regeneration Research, 2015
The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation.
Umar Hayat, Shuxin Li, Yosuke Ohtake
openaire   +4 more sources

Regulating synchronous oscillations of cerebellar granule cells by different types of inhibition.

PLoS Computational Biology, 2021
Synchronous oscillations in neural populations are considered being controlled by inhibitory neurons. In the granular layer of the cerebellum, two major types of cells are excitatory granular cells (GCs) and inhibitory Golgi cells (GoCs).
Yuanhong Tang, Lingling An, Quan Wang, Jian K Liu   +3 more
doaj   +1 more source