Results 91 to 100 of about 123,000 (283)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effects of Biological Adhesion on the Hydrodynamic Characteristics of Different Panel Net Materials: A BP Neural Network Approach

Journal of Marine Science and Engineering
Biofouling is a serious problem in marine aquaculture facilities, exerting several negative effects on cage structures. In this study, different materials of nets were placed in the Fujian Sea area of China, and the main biological adhesion species were ...
Yongli Liu, Wei Liu, Lei Wang, Minghua Min, Lei Li, Liang Wang, Shuo Ma   +6 more
doaj   +1 more source

Accurate clinical toxicity prediction using multi-task deep neural nets and contrastive molecular explanations. [PDF]

Sci Rep, 2023
Sharma B, Chenthamarakshan V, Dhurandhar A, Pereira S, Hendler JA, Dordick JS, Das P.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Estimação do volume de árvores utilizando redes neurais artificiais Estimate of tree volume using artificial neural nets

Revista Árvore, 2009
Rede neural artificial consiste em um conjunto de unidades que contêm funções matemáticas, unidas por pesos. As redes são capazes de aprender, mediante modificação dos pesos sinápticos, e generalizar o aprendizado para outros arquivos desconhecidos.
Eric Bastos Gorgens, Helio Garcia Leite, Heleno do Nascimento Santos, José Marinaldo Gleriani   +3 more
doaj   +1 more source

Plant recognition by AI: Deep neural nets, transformers, and kNN in deep embeddings. [PDF]

Front Plant Sci, 2022
Picek L, Šulc M, Patel Y, Matas J.
europepmc   +1 more source

User's guide for NETS/PROSSS [PDF]

Expensive analysis programs are often combined with optimization procedures to solve engineering problems. To obtain an optimal solution requires numerous iterations between the analysis program and the optimizer.
Lamarsh, William J., II, Rogers, James L.   +1 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Segmentation and Location Computation of Bin Objects

International Journal of Advanced Robotic Systems, 2008
In this paper we present a stereo vision based system for segmentation and location computation of partially occluded objects in bin picking environments. Algorithms to segment partially occluded objects and to find the object location [midpoint,x, y and
C.R. Hema, M.P. Paulraj, R. Nagarajan, Sazali Yaacob   +3 more
doaj