Results 71 to 80 of about 15,727 (262)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Effects of Biological Adhesion on the Hydrodynamic Characteristics of Different Panel Net Materials: A BP Neural Network Approach

Journal of Marine Science and Engineering
Biofouling is a serious problem in marine aquaculture facilities, exerting several negative effects on cage structures. In this study, different materials of nets were placed in the Fujian Sea area of China, and the main biological adhesion species were ...
Yongli Liu, Wei Liu, Lei Wang, Minghua Min, Lei Li, Liang Wang, Shuo Ma   +6 more
doaj   +1 more source

Plant recognition by AI: Deep neural nets, transformers, and kNN in deep embeddings. [PDF]

Front Plant Sci, 2022
Picek L, Šulc M, Patel Y, Matas J.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Segmentation and Location Computation of Bin Objects

International Journal of Advanced Robotic Systems, 2008
In this paper we present a stereo vision based system for segmentation and location computation of partially occluded objects in bin picking environments. Algorithms to segment partially occluded objects and to find the object location [midpoint,x, y and
C.R. Hema, M.P. Paulraj, R. Nagarajan, Sazali Yaacob   +3 more
doaj  

Accurate clinical toxicity prediction using multi-task deep neural nets and contrastive molecular explanations. [PDF]

Sci Rep, 2023
Sharma B, Chenthamarakshan V, Dhurandhar A, Pereira S, Hendler JA, Dordick JS, Das P.   +6 more
europepmc   +1 more source

Differential Bayesian Neural Nets

CoRR, 2019
Neural Ordinary Differential Equations (N-ODEs) are a powerful building block for learning systems, which extend residual networks to a continuous-time dynamical system. We propose a Bayesian version of N-ODEs that enables well-calibrated quantification of prediction uncertainty, while maintaining the expressive power of their deterministic counterpart.
Andreas Look, Melih Kandemir
openaire   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

PIPENN: protein interface prediction from sequence with an ensemble of neural nets. [PDF]

Bioinformatics, 2022
Stringer B, de Ferrante H, Abeln S, Heringa J, Feenstra KA, Haydarlou R.   +5 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source