Results 191 to 200 of about 1,681,568 (307)

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Human Spinal Cord GABAergic Neural Progenitor Cell. [PDF]

Cell Prolif
Xu J, Zhang X, Ma A, Hao J, Li T, Fu B, Ma L, Liu Y, Xiang P, Qian K, Han X, Li Y, Zhu L, Li Q, Wei Q, Wu T, Wang L, Cao J, Li K, Zhao H, Niu S, Hu B, Zhao T, Chen H.   +23 more
europepmc   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Polycystin-1 Controls Cell Cycle Kinetics, Cell Cycle Exit, and Differentiation of Neural Progenitor Cells. [PDF]

FASEB J
Winokurow N, Schumacher S.
europepmc   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

Meis1 isoform diversity orchestrates neural progenitor differentiation by regulating ATOH1 degradation at distinct subcellular compartments. [PDF]

PLoS Biol
Owa T, Adachi T, Shiraishi R, Ichijo K, Ji K, Mizuno M, Suyama K, Nishitani K, Hasegawa I, Sone M, Kawauchi D, Nishioka T, Taya S, Suzuki Y, Kaibuchi K, Miyashita S, Hoshino M.   +16 more
europepmc   +1 more source

An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling

Advanced Science, EarlyView.
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen, Alexander Chen, Quincy Lyons, Van K. Ninh, Maxwell C. McCabe, Colin Luo, Benjamin D. Bridgelal, Connor Uhre, Julian Cheng, Kate E. Reimold, Selena Cao, Kirk C. Hansen, Kevin R. King, Karen L. Christman   +13 more
wiley   +1 more source

Current status of neural progenitor/stem cells for spinal cord injury: fundamental research and clinical trials. [PDF]

Front Neurol
Chen XX, Yin Z, Zhang XH, Hao J, Zhou Q, Yu JA, Wu J.   +6 more
europepmc   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Direct and capacitive electrical stimulation shapes neural progenitor cell survival and orientation on conductive scaffolds. [PDF]

Sci Rep
McConnell KW, Thompson KJ, Spaid M, Paukshto M, Dai H, Shaik ZF, Jiang G, Bakdounes H, Shabestari SK, George PM.   +9 more
europepmc   +1 more source