Results 211 to 220 of about 1,681,568 (307)

Engineering Intelligent iPSC Biomanufacturing: Integrating Robotic Automation, AI, and Process Control

Advanced Intelligent Systems, EarlyView.
This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee, Roma Desai, Byunggik Kim, Deok‐Ho Kim   +3 more
wiley   +1 more source

An iPSC-derived neural progenitor cell therapy for subacute spinal cord injury: a phase 1 trial with long-term follow-up. [PDF]

Nat Med
Sugai K, Tsuji O, Fujiyoshi K, Ozaki M, Abe T, Kohzuki T, Okawara H, Sawada T, Sumida M, Yoshioka E, Shofuda T, Kawashima S, Yamaguchi R, Shinozaki M, Takasu N, Nagoshi N, Okubo T, Kohyama J, Maeda T, Yato Y, Kanemura Y, Yamanaka S, Nakamura M, Okano H.   +23 more
europepmc   +1 more source

A Novel Homozygous Nonsense Variant in DCHS1 in a Brazilian Patient With Van Maldergem Syndrome Type 1: Clinical Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Van Maldergem syndrome (VMLDS) is an ultra‐rare autosomal recessive disorder characterized by craniofacial dysmorphism, intellectual disability, hypotonia, skeletal anomalies, and feeding difficulties. It is caused by biallelic variants in DCHS1 or FAT4 genes.
Gabriela Roldão Correia‐Costa, Bruna Fagundes Rodrigues Alaite, Vera Lúcia Gil‐da‐Silva‐Lopes, Carlos Eduardo Steiner, Társis Paiva Vieira   +4 more
wiley   +1 more source

Metabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development. [PDF]

Cancer Metastasis Rev
Lee YHG, Tsoli M, Shi YC, Ip CK, Ziegler D.   +4 more
europepmc   +1 more source

Pediatric Human Olfactory Epithelium Mirrors Adult Structure and Function in a Human Olfactory Organoid Model

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Objective This study investigated the developmental differences in structure, gene expression, and function of human olfactory epithelium (OE) using pediatric and adult specimens and human olfactory organoids. Background Olfactory dysfunction (OD) is characterized by loss or alterations in the sense of smell and has an age‐related increase in ...
Randy Bach, Ankit Chauhan, Michael Xiang, Kang‐Hoon Kim, James N. Palmer, Nithin D. Adappa, Michael A. Kohanski, Noam A. Cohen, Hong Wang, Jennifer E. Douglas   +9 more
wiley   +1 more source

The development of a methodology to measure primary ciliary length in neural progenitor cells with a target molecule knocked down. [PDF]

Biochem Biophys Rep
Saito M, Otsu W, Ishibashi K, Atsumi GI.
europepmc   +1 more source

Nasal Tuft Cell Markers Are Predictive of Overall Survival in Sinonasal Neuroendocrine and Sinonasal Undifferentiated Carcinomas

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are rare aggressive malignancies with no established prognostic markers. Because features of POU2F3+ small cell lung carcinomas have been identified in both tumors, we evaluated immunostaining for POU2F3, a tuft cell transcription factor, and ...
Nikolina Dioufa, Ricardo V. Bruneto, Jennifer E. Douglas, Nithin D. Adappa, James N. Palmer, Noam A. Cohen, Michael A. Kohanski   +6 more
wiley   +1 more source

Bioreactor expansion of human neural progenitor cells for exosome scalable production and miRNA-engineering. [PDF]

J Biol Eng
Corraliza-Gomez M, Ianni M, Nogueira DES, Salvador WOS, Miguéis M, Garcia-Alloza M, Rodrigues CAV, Cabral JMS, Brites D.   +8 more
europepmc   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

CRL4^AMBRA1 is a key mediator for AKT-dependent cell cycle control in neural progenitor cells. [PDF]

EMBO Rep
Wang H, Liu P, Wang R, Gu H, Zhu T, Chen G, Yang JJ.   +6 more
europepmc   +1 more source