Results 221 to 230 of about 1,681,568 (307)

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

West Nile virus and Zika virus infections induce aggresome formation in human neural progenitor and A549 cells. [PDF]

J Virol
Basu M, Espínola EE, Niu W, Wen Z, Brinton MA.   +4 more
europepmc   +1 more source

Distribution of doublecortin in the developing retina of birds: A comparative analysis

The Anatomical Record, EarlyView.
Abstract The avian retina presents an elegant and highly accessible model for investigating the spatial and temporal dynamics of neurogenesis within the central nervous system. In recent years, the microtubule cytoskeleton has emerged not merely as a structural scaffold, but as a dynamic regulator of the transition of a morphologically homogeneous pool
Javier Francisco‐Morcillo, José Antonio de Mera‐Rodríguez, Violeta Calle‐Guisado, Gervasio Martín‐Partido, Joaquín Rodríguez‐León, Guadalupe Álvarez‐Hernán   +5 more
wiley   +1 more source

Synthetic lumen rounding directs neural progenitor division mode

Marchenko M, Martínez Ara G, Pulikkal J, Ishihara K, Ebisuya M.   +4 more
europepmc   +1 more source

Changes in neural progenitor lineage composition during astrocytic differentiation of human iPSCs. [PDF]

Elife
Li Z, Cardo LF, Rokicki M, Monzón-Sandoval J, Volpato V, Wessely F, Webber C, Li M.   +7 more
europepmc   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

DNA Methylation Landscape of ReNcell Common Neural Progenitor Cell Lines Reveals Distinct Lineage Bias. [PDF]

Biology (Basel)
Gyimesi M, Nguyen DLB, Peall IW, Okolicsanyi RK, Haupt LM.   +4 more
europepmc   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Preclinical biodistribution and safety evaluation of human iPSC-derived dopaminergic neural progenitor cells for Parkinson's disease. [PDF]

Front Cell Dev Biol
Huang Y, Wen H, Li L, Li L, Li Q, Qin C, Mao Y, Lin Z, Jiang H, Zhu F, Li X, Geng X.   +11 more
europepmc   +1 more source

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source