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Fate restrictions in embryonic neural progenitors
Current Opinion in Neurobiology, 2021The vertebrate central nervous system (CNS) is a fantastically complex organ composed of dozens of cell types within the neural and glial lineages. Its organization is laid down during development, through the localized and sequential production of subsets of neurons with specific identities.
Evelyne, Fischer, Xavier, Morin
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Neural Stem Cells: Progenitors or Panacea?
Developmental Neuroscience, 2004Are neural stem cells (NSCs) maintained as totipotent precursors by the specialized environment within the stem cell niche or are they simply progenitors, which, while retaining their ability to proliferate, are parcellated and restricted along with their postmitotic brethren?
Corinna, Klein, Gord, Fishell
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Science, 2020
Neurodevelopment Symptoms of Huntington's disease (HD) manifest in adulthood despite the aberrant protein being present much earlier in persons carrying the disease-causing mutation. Barnat et al. studied the cellular effects of the HD mutation on human and mouse fetal brain development (see the Perspective by DiFiglia).
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Neurodevelopment Symptoms of Huntington's disease (HD) manifest in adulthood despite the aberrant protein being present much earlier in persons carrying the disease-causing mutation. Barnat et al. studied the cellular effects of the HD mutation on human and mouse fetal brain development (see the Perspective by DiFiglia).
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TOX3 regulates neural progenitor identity
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016The human genomic locus for the transcription factor TOX3 has been implicated in susceptibility to restless legs syndrome and breast cancer in genome-wide association studies, but the physiological role of TOX3 remains largely unknown. We found Tox3 to be predominantly expressed in the developing mouse brain with a peak at embryonic day E14 where it co-
Sanjeeb Kumar Sahu +12 more
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Glia as neural progenitor cells
Trends in Neurosciences, 2003Recent studies have substantially expanded our conception of the roles for glia in function and maintenance of the adult nervous system. Of these reports, several have re-examined the lineage relationships among neural stem cells, their early radial glial derivatives and their mitotically competent neurogenic daughters.
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Modeling FXS with Mouse Neural Progenitors
2019The neurosphere assay is a widely used method to culture neural precursor cells (NPCs), which include mixed populations of neural stem and progenitor cells, from the mammalian central nervous system. Fmr1-knockout (KO) mice generated to model fragile X syndrome (FXS) recapitulate the major phenotype of FXS.
Castren Maija Liisa +1 more
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Neural progenitors and stem cells: mechanisms of progenitor heterogeneity
Current Opinion in Neurobiology, 1998Heterogeneity among progenitor cells in the vertebrate nervous system has been documented with increasing frequency over the past few years. It has become clear that differences in progenitor cells help to determine when and how they respond to environmental signals.
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Asymmetric division of Drosophila neural progenitors
Current Opinion in Genetics & Development, 2002Asymmetric division is a fundamental mechanism for generating cellular diversity. Studies on Drosophila neural progenitors have provided valuable insight into how evolutionarily conserved protein cassettes may be differentially deployed in different developmental contexts to mediate asymmetric divisions. Recent findings also suggest possible mechanisms
Chia, W, Yang, X H
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Neural Crest Stem and Progenitor Cells
Annual Review of Cell and Developmental Biology, 2006Neural crest cells are a multipotent, migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. These include bones; tendons; neurons; glia; melanocytes; and connective, endocrine, and adipose tissue.
Jennifer F, Crane, Paul A, Trainor
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Isolation of Adult Hippocampal Neural Progenitors
2010Adult neurogenesis, or the creation of new neurons in adult organisms, is an exciting recent area of neurological research. The subgranular zone of the adult hippocampus is one area where hippocampal neural progenitors generate new neurons that functionally integrate into existing neuronal circuitry.
Joseph, Peltier +2 more
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