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Recent Advances in 3D Models of the Nervous System for Neural Regeneration Research and Drug Development

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Hui Zhu   +14 more
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Cytokines in neural regeneration

Current Opinion in Neurobiology, 1992
Growth factors with already established multiple effects on non-neural cells continue to be of considerable interest to researchers with regard to the nervous system, where regulation of cell maintenance and plasticity in relation to lesion and regeneration is part of their functional repertoire.
K, Unsicker   +3 more
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Neural Regeneration

2012
Regeneration of the nervous system requires either the repair or replacement of nerve cells that have been damaged by injury or disease. While lower organisms possess extensive capacity for neural regeneration, evolutionarily higher organisms including humans are limited in their ability to regenerate nerve cells, posing significant issues for the ...
Melissa M, Steward   +2 more
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Neural Regeneration: Lessons from Regenerating and Non-regenerating Systems

Molecular Neurobiology, 2012
One only needs to see a salamander regrowing a lost limb to become fascinated by regeneration. However, the lack of robust axonal regeneration models for which good cellular and molecular tools exist has hampered progress in the field. Nevertheless, the nervous system has been revealed to be an excellent model to investigate regeneration.
Leonardo M R, Ferreira   +3 more
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Approaches for Neural Tissue Regeneration

Stem Cell Reviews and Reports, 2013
There is currently no treatment for neurodegenerative diseases such as Parkinson's or Alzheimer's diseases. While spinal cord injury has no treatment either, nerve injuries are being treated with autologous grafts, a procedure that in turn translates into a loss of function in the donor area.
Loïc, Binan   +3 more
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The Molecular Basis of Neural Regeneration

Neurosurgery, 2003
THE CENTRAL NERVOUS SYSTEM (CNS) is incapable of meaningful regeneration of lost neurons or axonal and dendritic connections after injury. This often results in permanent and severe loss of neurological function. The CNS regenerative process is unsuccessful for at least three reasons: neurons are highly susceptible to death after CNS injury; the CNS ...
W Bradley, Jacobs, Michael G, Fehlings
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How the Neural Retina Regenerates

2000
The rules that govern cellular behavior during development and regeneration of tissues are complex and enigmatic, but substantial progress is being made toward understanding the molecular basis of proliferation and differentiation. Although most of the recent mechanistic insights have been gained from studies of embryonic development, the capacity of ...
P A, Raymond, P F, Hitchcock
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