Results 61 to 70 of about 215,731 (353)

The killifish visual system as an in vivo model to study brain aging and rejuvenation

npj Aging and Mechanisms of Disease, 2021
Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality of elderly.
Sophie Vanhunsel, Steven Bergmans, An Beckers, Isabelle Etienne, Jolien Van houcke, Eve Seuntjens, Lut Arckens, Lies De Groef, Lieve Moons   +8 more
doaj   +1 more source

Planarian GSK3s are involved in neural regeneration [PDF]

Development Genes and Evolution, 2008
Glycogen synthase kinase-3 (GSK3) is a key element in several signaling cascades that is known to be involved in both patterning and neuronal organization. It is, therefore, a good candidate to play a role in neural regeneration in planarians. We report the characterization of three GSK3 genes in Schmidtea mediterranea. Phylogenetic analysis shows that
Teresa, Adell, Maria, Marsal, Emili, Saló   +2 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis

Journal of Alzheimer's Disease Reports
Background Sleep disorders are a significant risk factor for cognitive decline and Alzheimer's disease (AD). However, preclinical studies investigating the effects of sleep deprivation (SD) on cognition and synaptic proteins have produced inconsistent ...
Hongqi Wang, Xin Mao, Siyu Liu, Jiacheng Zhang, Enze Li, Yizhi Song, Hui Li, Lirong Chang, Yan Wu   +8 more
doaj   +1 more source

Using Crosslinked Hyaluronic Acid (HA) and Collagen Scaffolds with Sustained Brain-Derived Neurotrophic Factor (BDNF) Release for Post-SCI Nerve Regeneration [PDF]

, 2018
Traumatic events resulting in spinal cord injuries (SCIs) often leave people paralyzed or with partial loss of motor function. The physical disabilities arising from traumatic events prevent people from functioning at the same level as pre-injury.
Doshi, Panth
core   +1 more source

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. [PDF]

, 2009
A principal objective of spinal cord injury (SCI) research is the restoration of axonal connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms would guide regenerating spinal cord axons to appropriate brainstem targets ...
Alto, Laura Taylor, Blesch, Armin, Conner, James M, Havton, Leif A, Hollis, Edmund R, Tuszynski, Mark H   +5 more
core   +2 more sources

Timing neural development and regeneration

Current Opinion in Neurobiology
Regulation of neural progenitor temporal identity is critical to control the chronological order of cell birth and generation of cell diversity in the developing central nervous system (CNS). Single-cell RNA sequencing studies have identified transcriptionally distinct early and late temporal identity states in mammalian neural progenitors in multiple ...
Seth Blackshaw, Michel Cayouette
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Selecting Optimal Combinations of Transcription Factors to Promote Axon Regeneration: Why Mechanisms Matter [PDF]

, 2016
Recovery from injuries to the central nervous system, including spinal cord injury, is constrained in part by the intrinsically low ability of many CNS neurons to mount an effective regenerative growth response.
Blackmore, Murray G., Venkatesh, Ishwariya   +1 more
core   +1 more source

Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. [PDF]

, 2017
Implanted biomaterials and biomedical devices generally induce foreign body reaction and end up with encapsulation by a dense avascular fibrous layer enriched in extracellular matrix.
Chu, Julia, Gong, Xiaohua, Huang, Wen-Chin, Li, Song, Li, Ye, Qiu, Xuefeng, Wang, Aijun, Wang, Dong, Wu, Fan, Xu, Kang   +9 more
core   +2 more sources