Results 51 to 60 of about 1,843,588 (298)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Optogenetics and its application in neural degeneration and regeneration

, 2017
Neural degeneration and regeneration are important topics in neurological diseases. There are limited options for therapeutic interventions in neurological diseases that provide simultaneous spatial and temporal control of neurons.
Ordaz, Josue D., Josue D Ordaz, Wei Wu, Xiao-Ming Xu, Wu, Wei, Xu, Xiao-Ming, JosueD Ordaz   +6 more
core   +1 more source

Neural dependency in wound healing and regeneration

Developmental Dynamics, 2023
AbstractIn response to injury, humans and many other mammals form a fibrous scar that lacks the structure and function of the original tissue, whereas other vertebrate species can spontaneously regenerate damaged tissues and structures. Peripheral nerves have been identified as essential mediators of wound healing and regeneration in both mammalian and
Alexandra Noble, Rozana Qubrosi, Solsa Cariba, Kayla Favaro, Samantha L. Payne   +4 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis

Journal of Alzheimer's Disease Reports
Background Sleep disorders are a significant risk factor for cognitive decline and Alzheimer's disease (AD). However, preclinical studies investigating the effects of sleep deprivation (SD) on cognition and synaptic proteins have produced inconsistent ...
Hongqi Wang, Xin Mao, Siyu Liu, Jiacheng Zhang, Enze Li, Yizhi Song, Hui Li, Lirong Chang, Yan Wu   +8 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Expression of BACE1 in the Rat Carotid Body

Frontiers in Physiology, 2020
This study explored the expression of BACE1 (β-amyloid precursor protein cleaving enzyme 1) in the rat carotid body and the effect of CIH (cyclic intermittent hypoxia) on the expression of BACE1.
Chaohong Li, Baosheng Zhao, Ya-nan Fan, Xianglei Jia, Yuzhen Liu   +4 more
doaj   +1 more source

Sleep deprivation aggravated amyloid β oligomers-induced damage to the cerebellum of rats: Evidence from magnetic resonance imaging

Aging Brain, 2023
For quite a long time, researches on Alzheimer's disease (AD) primarily focused on the cortex and hippocampus, while the cerebellum has been ignored because of its abnormalities considered to appear in the late stage of AD.
Wensheng Guo, Xin Mao, Ding Han, Hongqi Wang, Wanning Zhang, Guitao Zhang, Ning Zhang, Binbin Nie, Hui Li, Yizhi Song, Yan Wu, Lirong Chang   +11 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Interpreting the neural code with formal concept analysis [PDF]

, 2012
This contribution is in volume 1 of 3 for this title.We propose a novel application of Formal Concept Analysis (FCA) to neural decoding: instead of just trying to figure out which stimulus was presented, we demonstrate how to explore the semantic ...
Endres, D, Foldiak, Peter
core   +2 more sources