Results 31 to 40 of about 1,843,588 (298)
Frontiers in Neuroscience, 2021 Background: The carotid body (CB) plays a critical role in oxygen sensing; however, the role of glutamatergic signaling in the CB response to hypoxia remains uncertain.
Chaohong Li +4 more
doaj +1 more source
Stem Cell Research & Therapy, 2019 s Background Spinal cord injury (SCI) is a complex and severe neurological condition. Mesenchymal stem cells (MSCs) and their secreted factors show promising potential for regenerative medicine.
Ya-Tzu Chen +6 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2012 Astrocytes perform many functions in the brain and spinal cord. Glucose metabolism is important for astroglial cells and astrocytes are the only cells with insulin receptors in the brain.
Akça, Hakan +6 more
core +1 more source
Rabphilin-3A undergoes phase separation to regulate GluN2A mobility and surface clustering
Nature Communications, 2023 GluN2A and GluN2B, two predominant Glu2N subunits of NMDARs in hippocampus and cortex, display distinct organization and mobility in the neuronal surface.
Lei Yang +9 more
doaj +1 more source
The DREADDful Hurdles and Opportunities of the Chronic Chemogenetic Toolbox
Cells, 2022 The chronic character of chemogenetics has been put forward as one of the assets of the technique, particularly in comparison to optogenetics. Yet, the vast majority of chemogenetic studies have focused on acute applications, while repeated, long-term ...
Marie Claes, Lies De Groef, Lieve Moons
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
, 2012 Several studies have demonstrated that human umbilical cord blood-derived mesenchymal stem cells can promote neural regeneration following brain injury.
Yoo, Sang Bae +9 more
core +1 more source
c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. [PDF]
, 2012 The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy +35 more
core +1 more source
Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System
Mediators of Inflammation, 2017 Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration.
Ilse Bollaerts +4 more
doaj +1 more source