Results 11 to 20 of about 1,843,588 (298)

Biomaterials and neural regeneration

Neural Regeneration Research, 2020
[[abstract]]Neural regeneration is a great clinical challenge in both the central nervous system (CNS) and the peripheral nervous system (PNS). Degeneration in the CNS caused by disease (such as Alzheimer’s or Parkinson’s diseases) or trauma (such as ...
Yi Liu, Shan-hui Hsu
openaire   +4 more sources

Functional brain regeneration in the acoel worm Symsagittifera roscoffensis [PDF]

, 2015
The ability of some animals to regrow their head and brain after decapitation provides a striking example of the regenerative capacity within the animal kingdom.
van Giesen, Lena, Heinrich Reichert, Reichert, Heinrich, Martinez, Pedro, Ricardo Neves, Hartenstein, Volker, Bernardo-Garcia, F. Javier, Lena van Giesen, Michael Brauchle, Pedro Martinez, Neves, Ricardo, Brauchle, Michael, F. Javier Bernardo-Garcia, Volker Hartenstein, Sprecher, Simon G., Giesen, Lena van, Xavier Bailly, Bailly, Xavier, Simon G. Sprecher   +18 more
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6’-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice

Frontiers in Immunology, 2023
Sialic acids are terminal sugars of the cellular glycocalyx and are highly abundant in the nervous tissue. Sialylation is sensed by the innate immune system and acts as an inhibitory immune checkpoint.
Tawfik Abou Assale, Thomas Kuenzel, Tamara Schink, Anahita Shahraz, Harald Neumann, Christine Klaus   +5 more
doaj   +1 more source

Low molecular weight polysialic acid binds to properdin and reduces the activity of the alternative complement pathway

Scientific Reports, 2022
Sialic acids as the terminal caps of the cellular glycocalyx play an essential role in self-recognition and were shown to modulate complement processes via interaction between α2,3-linked sialic acids and complement factor H. Previously, it was suggested
Anahita Shahraz, Yuchen Lin, Joshua Mbroh, Jonas Winkler, Huan Liao, Marie Lackmann, Annemarie Bungartz, Peter F. Zipfel, Christine Skerka, Harald Neumann   +9 more
doaj   +1 more source

MicroRNA-142a-3p regulates neurogenic skeletal muscle atrophy by targeting Mef2a

Molecular Therapy: Nucleic Acids, 2023
Peripheral nerve injury can lead to progressive muscle atrophy and poor motor function recovery, which is a difficult point of treatment, and the mechanism needs to be further explored.
Xinyi Gu, Shen Wang, Dongdong Li, Bo Jin, Zhidan Qi, Jin Deng, Chen Huang, Xiaofeng Yin   +7 more
doaj   +1 more source

The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway

Cell Reports, 2019
Summary: Under food deprivation conditions, Drosophila larvae exhibit increases in locomotor speed and synaptic bouton numbers at neuromuscular junctions (NMJs).
Keisuke Kamimura, Aiko Odajima, Yuko Ikegawa, Chikako Maru, Nobuaki Maeda   +4 more
doaj   +1 more source

Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C

EMBO Molecular Medicine, 2022
Major depressive disorder with suicide behavior (sMDD) is a severe mood disorder, bringing tremendous burden to family and society. Although reduced gamma amino butyric acid (GABA) level has been observed in postmortem tissues of sMDD patients, the ...
Kaiqin Lu, Yuan Hong, Mengdan Tao, Luping Shen, Zhilong Zheng, Kaiheng Fang, Fang Yuan, Min Xu, Chun Wang, Dongya Zhu, Xing Guo, Yan Liu   +11 more
doaj   +1 more source

Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury

, 2022
Injuries to the central nervous system (CNS) such as stroke, brain, and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon regeneration.
Chow, Shing Fung, Tsang, Chi Kwan, Li, M, Weng, Jing-Wen, Ho, ES, Chow, SF, Ho, Eric S., WENG, J, Tsang, CK, Li, Ming-Xi   +9 more
core   +1 more source

Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule

Scientific Reports, 2017
Human pluripotent stem cells (hPSCs) play important role in studying the function of human glutamatergic neurons and related disease pathogenesis. However, the current hPSC-derived cortical system produced a significant number of inhibitory GABAergic ...
Shi-Ying Cao, Yao Hu, Cheng Chen, Fang Yuan, Min Xu, Qi Li, Kai-Heng Fang, Yaoyu Chen, Yan Liu   +8 more
doaj   +1 more source

Ischemic postconditioning ameliorates acute kidney injury induced by limb ischemia/reperfusion via transforming TLR4 and NF-κB signaling in rats

Journal of Orthopaedic Surgery and Research, 2021
Background The present study investigated the influence of ischemic postconditioning (I-postC) on the adjustment of renal injury after limb ischemia-reperfusion (I/R) injury, to elucidate the mechanisms of the Toll-like receptor 4 (TLR 4)/NF-κB signaling
Zhongdi Liu, Wei Huang, Yifan Chen, Zhe Du, Fengxue Zhu, Tianbing Wang, Baoguo Jiang   +6 more
doaj   +1 more source