Results 21 to 30 of about 108,190 (264)
Frontiers in Neuroscience, 2021 Background: The carotid body (CB) plays a critical role in oxygen sensing; however, the role of glutamatergic signaling in the CB response to hypoxia remains uncertain.
Chaohong Li +4 more
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Acta Neuropathologica Communications, 2023 The multifaceted nature of neuroinflammation is highlighted by its ability to both aggravate and promote neuronal health. While in mammals retinal ganglion cells (RGCs) are unable to regenerate following injury, acute inflammation can induce axonal ...
Lien Andries +10 more
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Stem Cell Research & Therapy, 2019 s Background Spinal cord injury (SCI) is a complex and severe neurological condition. Mesenchymal stem cells (MSCs) and their secreted factors show promising potential for regenerative medicine.
Ya-Tzu Chen +6 more
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The DREADDful Hurdles and Opportunities of the Chronic Chemogenetic Toolbox
Cells, 2022 The chronic character of chemogenetics has been put forward as one of the assets of the technique, particularly in comparison to optogenetics. Yet, the vast majority of chemogenetic studies have focused on acute applications, while repeated, long-term ...
Marie Claes, Lies De Groef, Lieve Moons
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System
Mediators of Inflammation, 2017 Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration.
Ilse Bollaerts +4 more
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The Application of Brain Organoids in Assessing Neural Toxicity
Frontiers in Molecular Neuroscience, 2022 The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases ...
Pan Fan +5 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Scientific ReportsRegenerative therapy based on mesenchymal stem cells (MSCs) is regarded as a promising strategy for treating Parkinson’s disease (PD). Previous studies have shown that mesenchymal stem cell transplantation has the potential to treat Parkinson’s disease ...
Chunjing Wang +10 more
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