Results 41 to 50 of about 108,190 (264)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis

Journal of Alzheimer's Disease Reports
Background Sleep disorders are a significant risk factor for cognitive decline and Alzheimer's disease (AD). However, preclinical studies investigating the effects of sleep deprivation (SD) on cognition and synaptic proteins have produced inconsistent ...
Hongqi Wang, Xin Mao, Siyu Liu, Jiacheng Zhang, Enze Li, Yizhi Song, Hui Li, Lirong Chang, Yan Wu   +8 more
doaj   +1 more source

Functional glutamate transporters are expressed in the carotid chemoreceptor

Respiratory Research, 2020
Background The carotid body (CB) plays a critical role in cyclic intermittent hypoxia (CIH)-induced chemosensitivity; however, the underlying mechanism remains uncertain. We have demonstrated the presence of multiple inotropic glutamate receptors (iGluRs)
Chaohong Li, Lu Huang, Xianglei Jia, Baosheng Zhao, Lingyun Chen, Yuzhen Liu   +5 more
doaj   +1 more source

Sleep deprivation aggravated amyloid β oligomers-induced damage to the cerebellum of rats: Evidence from magnetic resonance imaging

Aging Brain, 2023
For quite a long time, researches on Alzheimer's disease (AD) primarily focused on the cortex and hippocampus, while the cerebellum has been ignored because of its abnormalities considered to appear in the late stage of AD.
Wensheng Guo, Xin Mao, Ding Han, Hongqi Wang, Wanning Zhang, Guitao Zhang, Ning Zhang, Binbin Nie, Hui Li, Yizhi Song, Yan Wu, Lirong Chang   +11 more
doaj   +1 more source

Timing neural development and regeneration

Current Opinion in Neurobiology
Regulation of neural progenitor temporal identity is critical to control the chronological order of cell birth and generation of cell diversity in the developing central nervous system (CNS). Single-cell RNA sequencing studies have identified transcriptionally distinct early and late temporal identity states in mammalian neural progenitors in multiple ...
Seth Blackshaw, Michel Cayouette
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The killifish visual system as an in vivo model to study brain aging and rejuvenation

npj Aging and Mechanisms of Disease, 2021
Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality of elderly.
Sophie Vanhunsel, Steven Bergmans, An Beckers, Isabelle Etienne, Jolien Van houcke, Eve Seuntjens, Lut Arckens, Lies De Groef, Lieve Moons   +8 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma

Brain and Behavior
Background: Glioma represent one of the most prevalent and lethal malignancies within the central nervous system. Recent studies have identified ITPRIPL1, a newly reported CD3ε‐inhibitory ligand, as a suppressor of T cell activation, thereby facilitating
Zou Xiaoyun, Ye Wenhao, Wu Huan, Yang Yuanyuan, Liu Changqing, Wen Hebao, Ma Caiyun   +6 more
doaj   +1 more source