Results 41 to 50 of about 1,843,588 (298)

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Nanotechnology Reviews, 2021
Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration.
Gu Xinyi, Chen Xiaoli, Tang Xiaoxuan, Zhou Zhihao, Huang Tingting, Yang Yumin, Ling Jue   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Biomaterials and 3D printing techniques for neural tissue regeneration

, 2016
Nerve regeneration involves a series of complex physiological phenomena. Larger peripheral nerve injuries must be surgically treated, typically with autografts harvested from elsewhere in the body.
Zhang, L.G., Se-Jun Lee, Nathan Castro, Lee, S.J., Castro, N., Zhu, W., Wei Zhu, Lijie Grace Zhang   +7 more
core   +1 more source

Genetically engineered BMSCs promote dopamine secretion and ameliorate motor dysfunction in a Parkinson’s disease rat model

Scientific Reports
Regenerative therapy based on mesenchymal stem cells (MSCs) is regarded as a promising strategy for treating Parkinson’s disease (PD). Previous studies have shown that mesenchymal stem cell transplantation has the potential to treat Parkinson’s disease ...
Chunjing Wang, Yang Liu, Junyan Chang, Yiqin He, Pan Yang, Jingjing Fu, Wanying Du, Caiyun Ma, Gaofeng Liu, Yu Guo, Changqing Liu   +10 more
doaj   +1 more source

The Application of Brain Organoids in Assessing Neural Toxicity

Frontiers in Molecular Neuroscience, 2022
The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases ...
Pan Fan, YuanHao Wang, Min Xu, Xiao Han, Yan Liu, Yan Liu   +5 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Peripheral nerve regeneration with conduits: use of vein tubes

, 2015
Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process.
Rodrigo Guerra Sabongi, Sabongi, Rodrigo Guerra [UNIFESP], Fernandes, Marcela [UNIFESP], Santos, João Baptista Gomes dos [UNIFESP], Marcela Fernandes, João Baptista Gomes dos Santos   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Communicating with the non-dominant hemisphere Implications for neurological rehabilitation

, 2013
Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language ...
Oliveira, Fabricio Ferreira de [UNIFESP], Bertolucci, Paulo Henrique Ferreira [UNIFESP], Marin, Sheilla de Medeiros Correia [UNIFESP]   +2 more
core   +1 more source

Large-Scale Integration of Single-Cell RNA-Seq Data Reveals Astrocyte Diversity and Transcriptomic Modules across Six Central Nervous System Disorders

Biomolecules, 2023
The dysfunction of astrocytes in response to environmental factors contributes to many neurological diseases by impacting neuroinflammation responses, glutamate and ion homeostasis, and cholesterol and sphingolipid metabolism, which calls for ...
Zhenwei Qian, Jinglin Qin, Yiwen Lai, Chen Zhang, Xiannian Zhang   +4 more
doaj   +1 more source