Results 51 to 60 of about 2,833,598 (231)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Neural Respiratory Drive during CO₂ Rebreathing Assessed by a Combined Esophageal Electrode Catheter

, 2011
Assessment of neural respiratory drive is useful for diagnosis and management of breathing difficulty. The diaphragm is the most important muscle of respiration, therefore its electrical activity during spontaneously breathing could be used to reflect ...
Kang Xin Tan, Yuan Ming Luo, Dong Xiao Lu   +2 more
core   +1 more source

The olfactory bulb theta rhythm follows all frequencies of diaphragmatic respiration in the freely behaving rat

Frontiers in Behavioral Neuroscience, 2014
Sensory-motor relationships are part of the normal operation of sensory systems. Sensing occurs in the context of active sensor movement, which in turn influences sensory processing. We address such a process in the rat olfactory system.
Daniel eRojas-Líbano, Daniel eRojas-Líbano, Donald E. Frederick, Donald E. Frederick, Jose Ignacio eEgaña, Leslie M. Kay, Leslie M. Kay, Leslie M. Kay   +7 more
doaj   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Central role of carotid body chemoreceptors in disordered breathing and cardiorenal dysfunction in chronic heart failure

Frontiers in Physiology, 2014
Oscillatory breathing patterns are observed in pre-term infants, patients with cardio-renal impairment, and in otherwise healthy humans exposed to high altitude.
Noah J Marcus, Rodrigo eDel Rio, Harold D Schultz   +2 more
doaj   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

Self-Explaining Neural Networks for Respiratory Sound Classification with Scale-free Interpretability

, 2023
Analysis of respiratory sounds is an area where deep neural networks (DNNs) may benefit clinicians and patients for diagnostic purposes due to their classification power. However, explaining the predictions made by DNNs remains a challenge.
Ren, Z, Nguyen, TT, Zahed, MM, Nejdl, W
core   +1 more source

Neuromuscular and neuromechanical assessments of respiratory performance in the mdx mouse model of Duchenne muscular dystrophy across the natural history of disease

Experimental Physiology
Duchenne muscular dystrophy (DMD) is a severe life‐limiting X‐linked neuromuscular disorder characterised by progressive skeletal muscle degeneration and respiratory failure. The mdx mouse, lacking dystrophin, is the most widely used preclinical model of
Michael N. Maxwell, Christopher G. Wilson, Mai K. Elmallah, Federica Trucco, Ken D. O'Halloran   +4 more
doaj   +1 more source

Age and estrogen-associated reductions in hypoxic ventilatory response and chemosensitivity in female rats

Frontiers in Physiology
Respiratory function is modulated by circulating steroid hormones. In female rats, steroid hormones fluctuate across the normal estrous cycle and decline with age, similar to human menopause.
Jessica M. L. Grittner, Rebecca Barok, Edgar Juarez Lopez, Misha Shah, Brendan J. Dougherty   +4 more
doaj   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source