Results 81 to 90 of about 2,833,598 (231)

Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans [PDF]

, 2010
We investigated the neural basis for spontaneous chemo-stimulated increases in ventilation in awake, healthy humans. Blood oxygen level dependent (BOLD) functional MRI was performed in nine healthy subjects using T2weighted echo planar imaging.
Critchley, Hugo D., R.S.J. Frackowiak (16047230), Frackowiak, R.S.J., McKay, Leanne C., Hugo Critchley (4461955), Frackowiak, R.S., Critchley, H.D., Frackowiak, Richard S J, McKay, L.C., K. Murphy (6727403), Corfield, D.R., Corfield, Douglas R., L.C. McKay (16047227), Corfield, Douglas, D.R. Corfield (16047233), Murphy, K., Murphy, Kevin   +16 more
core   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Importância da avaliação funcional do controle da ventilação** Apresentada no curso satéllite da Reunião da SPP em Counbra

Revista Portuguesa de Pneumologia, 1999
RESUMO: Estudamos o controle da respiração com a finalidade primordial de avaliar a dispneia. A presente abordagem deve ser feita a vários niveis, uma vez que o centro respiratório pode estar integro mas os efectores a nivel dos circuitos neuronais podan
Miguel Mota Carmo, Cristina Barbara, Teresa Ferreira, Sara Ferreira, Rita Ferreira, Antonio Rendas   +5 more
doaj   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Respiratory health and endotoxin: associations and modification by CD14/-260 genotype [PDF]

, 2011
Exposure to endotoxin has been associated with increased respiratory symptoms and decrements in lung function in occupational settings but little is known about the health effects of domestic exposure in adults.
Jarvis, D., Heederik, D., Svanes, C., M. Kogevinas, Dep IRAS, Norbäck D, D. Jarvis, J. P. Zock, Olivieri, Mario, Bakolis, I., Jarvis, D, C. M. Chen, on behalf of the Indoor group of the ECRHS, S. Guerra, D. Norback, G. Verlato, Norback, D., Bakolis I, Ramasamy, A, Svanes C, Jarvis D, Ramasamy A, Chen CM, J. Heinrich, Guerra, S., Chen, C.M., Chen, C. M., ?, ?, Castro-Giner, F., D. Heederik, null null, Kogevinas, M, Zock JP, Doekes, G., A. Nevalainen, VERLATO, Giuseppe, Nevalainen, A., HITEA Study Group (), Nevalainen, A, Chen, CM, Olivieri, M., Norbäck, D, Guerra, S, Svanes, C, Indoor Group of the ECRHS, I. Bakolis, Castro-Giner, F, Norbäck, Dan,, Kogevinas, M., Verlato, G., Heinrich, J, Risk Assessment of Toxic and Immunomodulatory Agents, Zock, JP, Bakolis, I, Olivieri, M, the Work Package 10 group of HITEA, Heinrich, J., Guerra S, Zock, J. P., Zock, J P, C. Svanes, Heinrich J, Kogevinas M, Chen, C M, Bakolis, I; id_orcid, A. Ramasamy, Verlato, G, Work Package 10 Group of HITEA, Nevalainen A, Doekes, G, Zock, J.P., G. Doekes, Doekes G, M. Olivieri, Heederick D, Ramasamy, A., Heederik, D, F. Castro-Giner   +77 more
core   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Neural respiratory drive in healthy subjects and in COPD

, 2009
The aim of the present study was to use the diaphragm electromyogram (EMG(di)) to compare levels of neural respiratory drive (NRD) in a cohort of healthy subjects and chronic obstructive pulmonary disease (COPD) patients, and to investigate the ...
Ward, K, Seymour, J, Reilly, Charles, Luo, Y-M, Polkey, M I, Rafferty, G F; id_orcid, Lunt, A, Moxham, J, Steier, J; id_orcid, Jolley, C J; id_orcid   +9 more
core   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source