Results 1 to 10 of about 441,743 (344)

Early Acquisition of Neural Crest Competence During hESCs Neuralization [PDF]

, 2010
Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates.
Bronner-Fraser, Marianne, Cattarossi, Giulio, Cimadamore, Flavio, Curchoe, Carol Lynn, Maurer, Jochen, McKeown, Sonja J., Nilbratt, Mats, Snyder, Evan Y., Terskikh, Alexey V.   +8 more
core   +24 more sources

Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury

Journal of Neuroinflammation, 2022
Background Immune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies.
Elizabeth S. Fisher, Matthew A. Amarante, Natasha Lowry, Steven Lotz, Farhad Farjood, Sally Temple, Caitlin E. Hill, Thomas R. Kiehl   +7 more
doaj   +1 more source

Increased expression of pathological markers in Parkinson’s disease dementia post-mortem brains compared to dementia with Lewy bodies

BMC Neuroscience, 2022
Background Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are common age-related neurodegenerative diseases comprising Lewy body spectrum disorders associated with cortical and subcortical Lewy body pathology.
Haitao Tu, Zhi Wei Zhang, Lifeng Qiu, Yuning Lin, Mei Jiang, Sook-Yoong Chia, Yanfei Wei, Adeline S. L. Ng, Richard Reynolds, Eng-King Tan, Li Zeng   +10 more
doaj   +1 more source

Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells

APL Bioengineering, 2023
During embryonic development, endothelial cells (ECs) undergo vasculogenesis to form a primitive plexus and assemble into networks comprised of mural cell-stabilized vessels with molecularly distinct artery and vein signatures. This organized vasculature
Taylor Bertucci, Shravani Kakarla, Max A. Winkelman, Keith Lane, Katherine Stevens, Steven Lotz, Alexander Grath, Daylon James, Sally Temple, Guohao Dai   +9 more
doaj   +1 more source

NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits

Journal of Neuroinflammation, 2022
Background Alcohol use disorders result from repeated binge and chronic alcohol consumption followed by negative effects, such as anxiety, upon cessation. This process is associated with the activation of NLRP3 inflammasome-mediated responses.
Ziyi Li, Olivia Ewi Vidjro, Gengni Guo, Yanfeng Du, Yao Zhou, Qian Xie, Jiaxin Li, Keqiang Gao, Li Zhou, Tengfei Ma   +9 more
doaj   +1 more source

The Effects of Extrinsic and Intrinsic Factors on Neurogenesis

Cells, 2023
In the mammalian brain, neurogenesis is maintained throughout adulthood primarily in two typical niches, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) of the lateral ventricles and in other nonclassic neurogenic areas (
Mei Jiang, Se Eun Jang, Li Zeng
doaj   +1 more source

Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C

EMBO Molecular Medicine, 2022
Major depressive disorder with suicide behavior (sMDD) is a severe mood disorder, bringing tremendous burden to family and society. Although reduced gamma amino butyric acid (GABA) level has been observed in postmortem tissues of sMDD patients, the ...
Kaiqin Lu, Yuan Hong, Mengdan Tao, Luping Shen, Zhilong Zheng, Kaiheng Fang, Fang Yuan, Min Xu, Chun Wang, Dongya Zhu, Xing Guo, Yan Liu   +11 more
doaj   +1 more source

Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model. [PDF]

G3 (Bethesda)
Adebambo TH, Medina-Flores F, Zhang S, Lerit DA.   +3 more
europepmc   +3 more sources

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

The Application of Brain Organoids in Assessing Neural Toxicity

Frontiers in Molecular Neuroscience, 2022
The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases ...
Pan Fan, YuanHao Wang, Min Xu, Xiao Han, Yan Liu, Yan Liu   +5 more
doaj   +1 more source