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Lessons Learned from Pioneering Neural Stem Cell Studies

Stem Cell Reports, 2017
As stem cell products are increasingly entering early stage clinical trials, we are learning from experience about how cell products may be best assessed for safety and efficacy.
Sally Temple, Lorenz Studer
doaj   +1 more source

Human organoids in basic research and clinical applications

Signal Transduction and Targeted Therapy, 2022
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from healthy individuals or patients that recapitulate the cellular heterogeneity ...
Xiao-Yan Tang, Shanshan Wu, Da Wang, Chu Chu, Yuan Hong, Mengdan Tao, Hao Hu, Min Xu, Xing Guo, Yan Liu   +9 more
doaj   +1 more source

Stem Cells in the Nervous System [PDF]

, 2014
Given their capacity to regenerate cells lost through injury or disease, stem cells offer new vistas into possible treatments for degenerative diseases and their underlying causes.
Doetsch, Fiona K., Henderson, Christopher E., Maldonado-Soto, Angel R., Oakley, Derek H., Stein, Joel, Wichterle, Hynek   +5 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division

Frontiers in Neuroscience, 2020
A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus of most mammals. These NSCs generate also astrocytes naturally and are capable of generating oligodendrocytes
Roberto Valcárcel-Martín, Roberto Valcárcel-Martín, Soraya Martín-Suárez, Teresa Muro-García, Teresa Muro-García, Oier Pastor-Alonso, Oier Pastor-Alonso, Fernando Rodríguez de Fonseca, Guillermo Estivil-Torrús, Juan Manuel Encinas, Juan Manuel Encinas, Juan Manuel Encinas   +11 more
doaj   +1 more source

Designing signaling environments to steer transcriptional diversity in neural progenitor cell populations [PDF]

, 2019
Stem cell populations within developing embryos are diverse, composed of many different subpopulations of cells with varying developmental potential. The structure of stem cell populations in cell culture remains poorly understood and presents a barrier ...
Chen, Sisi, Park, Jong H., Rivaud, Paul, Thomson, Matt, Tsou, Tiffany   +4 more
core  

Neural Stem Cells in the Diabetic Brain [PDF]

Stem Cells International, 2012
Experimental diabetes in rodents rapidly affects the neurogenic niches of the adult brain. Moreover, behavioral disorders suggest that a similar dysfunction of the neurogenic niches most likely affects diabetic and prediabetic patients. Here, we review our present knowledge about adult neural stem cells, the methods used for their study in diabetic ...
Tomás P. Bachor, Ángela M. Suburo
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2

The EMBO Journal, 2023
Lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG).
Oier Pastor-Alonso, Anum Syeda Zahra, Bente Kaske, Fernando García-Moreno, Felix Tetzlaff, Enno Bockelmann, Vanessa Grunwald, Soraya Martín-Suárez, Kristoffer Riecken, Otto Wilhelm Witte, Juan Manuel Encinas, Anja Urbach   +11 more
doaj   +1 more source

Generation of an iPSC line (CRICKi001-A) from an individual with a germline SMARCA4 missense mutation and autism spectrum disorder

Stem Cell Research, 2021
Germline missense mutations in the BAF swi/snf chromatin remodeling subunit SMARCA4 are associated with neurodevelopmental disorders, including Coffin Siris Syndrome (CSS). Here, we generated an induced pluripotent stem cell line from a male patient with
Liani G. Devito, Lyn Healy, Shehla Mohammed, Francois Guillemot, Cristina Dias   +4 more
doaj   +1 more source