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Cell ReportsSummary: Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes.
Tony Kwan, Keith Murai, Guoping Feng
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eLife, 2023 Mononuclear cells are involved in the pathogenesis of retinal diseases, including age-related macular degeneration (AMD). Here, we examined the mechanisms that underlie macrophage-driven retinal cell death. Monocytes were extracted from patients with AMD
Sarah Elbaz-Hayoun +4 more
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Biomedicines, 2023 Autism spectrum disorder (ASD) prevalence is emerging with an unclear etiology, hindering effective therapeutic interventions. Recent studies suggest potential renin–angiotensin system (RAS) alterations in different neurological pathologies. However, its
Ayat I. Samra +5 more
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Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects
Frontiers in Aging Neuroscience, 2021 While the central nervous system compromises 2% of our body weight, it harbors up to 25% of the body’s cholesterol. Cholesterol levels in the brain are tightly regulated for physiological brain function, but mounting evidence indicates that excessive ...
Femke M. Feringa +3 more
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Neuropil Alteration of the Habenula Nucleus in the Experimental Model of Schizophrenia Induced by Ketamine [PDF]
International Journal of Scientific Research in Dental and Medical Sciences, 2023 Background and aim: Neuropil is a densely packed network of glial processes, neuronal processes, extracellular matrix, and microvascular in the central nervous system.
Shahriar Ahmadpour
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A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation
EMBO Molecular Medicine, 2020 Enteric glial cells (EGC) modulate motility, maintain gut homeostasis, and contribute to neuroinflammation in intestinal diseases and motility disorders.
Reiner Schneider +15 more
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Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome
Frontiers in Cell and Developmental Biology, 2020 Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity.
Soraya Martín-Suárez +6 more
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Frontiers in Cell and Developmental Biology, 2022 Hypoxia and hypoxia-reoxygenation are frequently developed through the course of many retinal diseases of different etiologies. Müller glial cells (MGCs), together with microglia and astrocytes, participate firstly in response to the injury and later in ...
Paula V. Subirada +11 more
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Antenatal Hypoxia Accelerates the Onset of Alzheimer’s Disease Pathology in 5xFAD Mouse Model
Frontiers in Aging Neuroscience, 2020 Alzheimer’s disease (AD) is a chronic neurodegenerative disorder associated with cognitive impairment and later dementia among the elderly. Mounting evidence shows that adverse maternal environments during the fetal development increase the risk of ...
Guofang Shen +4 more
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Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
Frontiers in Aging Neuroscience, 2021 Post-stroke Epilepsy (PSE) is one of the most common forms of acquired epilepsy, especially in the elderly population. As people get increasingly older, the number of stroke patients is expected to rise and concomitantly the number of people with PSE ...
Anna Regina Tröscher +10 more
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