Results 21 to 30 of about 55,381 (288)
A Synthesized Glucocorticoid- Induced Leucine Zipper Peptide Inhibits Retinal Müller Cell Gliosis
Frontiers in Pharmacology, 2018 Purpose: The anti-inflammatory activities of protein glucocorticoid-induced leucine zipper (GILZ) have been demonstrated in vivo and in vitro. Here, we examined the potential effect of a synthetic peptide derived from the leucine zipper motif and proline-
Ruiping Gu +7 more
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Gliosis and Neurodegenerative Diseases: The Role of PET and MR Imaging
Frontiers in Cellular Neuroscience, 2020 Glial activation characterizes most neurodegenerative and psychiatric diseases, often anticipating clinical manifestations and macroscopical brain alterations. Although imaging techniques have improved diagnostic accuracy in many neurological conditions,
Carlo Cavaliere +5 more
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Journal of Neuroinflammation, 2011 Purpose Microglia and Müller cells are prominent participants in retinal responses to injury and disease that shape eventual tissue adaptation or damage.
Wang Minhua +4 more
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Hypothalamic inflammation and gliosis in obesity [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2015 Hypothalamic inflammation and gliosis are recently discovered mechanisms that may contribute to obesity pathogenesis. Current research in this area suggests that investigation of these central nervous system responses may provide opportunities to develop new weight loss treatments.In rodents, hypothalamic inflammation and gliosis occur rapidly with ...
Mauricio D, Dorfman, Joshua P, Thaler
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Experimental Biology and Medicine, 1962 ConclusionMorphologic and histochemical studies of glial reaction during Wallerian degeneration in the dorsal column of the spinal cord have shown that reactive gliosis is independent of alterations of the blood-spinal cord barrier. These data suggest that substances inducing gliosis may pre-exist in normal central nervous system tissue.
K A, OSTERBERG, L W, WATTENBERG
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BMP pathway and reactive retinal gliosis [PDF]
, 2012 Reactive gliosis is known to have a beneficial and a degenerative effect following injury to neurons. Although many factors have been implicated in reactive gliosis, their role in regulating this change is still unclear.
Dharmarajan, Subramanian
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Antioxidants, 2021 Dysregulated glutamate signaling, leading to neuronal excitotoxicity and death, has been associated with neurodegenerative pathologies. 17β-estradiol (E2) is a human steroid hormone having a role in reproduction, sexual maturation, brain health and ...
Ibrahim Khan +3 more
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Searching for Neuropathology: Gliosis in Schizophrenia [PDF]
Biological Psychiatry, 2011 The neuropathology of schizophrenia remains elusive. One indication of this elusiveness is that the literature, in contrast to that on the neuropathology of almost any other disease, deals predominantly with measures of normal structures rather than with the demonstration and characterization of pathological structures.
Tatiana P, Schnieder, Andrew J, Dwork
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Pharmaceuticals, 2020 Kinins are vasoactive peptides and mediators of inflammation, which signal through two G protein-coupled receptors, B1 and B2 receptors (B1R, B2R). Recent pre-clinical findings suggest a primary role for B1R in a rat model of wet age-related macular ...
Rahmeh Othman +3 more
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