Results 131 to 140 of about 1,438,323 (398)

Mitochondrial Stress Response in Neural Stem Cells Exposed to Electronic Cigarettes. [PDF]

, 2019
Stem cells provide a sensitive model to study exposure to toxicants, such as cigarette smoke. Electronic cigarettes (ECs) are popular nicotine delivery devices, often targeted to youth and pregnant mothers. However, little is known about how chemicals in
Chaili, Angela, Leung, Sara, Omaiye, Esther, Phandthong, Rattapol, Talbot, Prue, Zahedi, Atena   +5 more
core  

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells

Nature Cell Biology, 2014
The vasculature is a prominent component of the subventricular zone neural stem cell niche. Although quiescent neural stem cells physically contact blood vessels at specialized endfeet, the significance of this interaction is not understood. In contrast,
C. Ottone, Benjamin Krusche, Ariadne Whitby, M. Clements, Giorgia Quadrato, M. Pitulescu, R. Adams, S. Parrinello   +7 more
semanticscholar   +1 more source

Current Status of Stem Cell-Derived Therapies for Parkinson’s Disease: From Cell Assessment and Imaging Modalities to Clinical Trials

Frontiers in Neuroscience, 2020
Curative therapies or treatments reversing the progression of Parkinson’s disease (PD) have attracted considerable interest in the last few decades. PD is characterized by the gradual loss of dopaminergic (DA) neurons and decreased striatal dopamine ...
Se Eun Jang, Lifeng Qiu, Ling Ling Chan, Ling Ling Chan, Eng-King Tan, Eng-King Tan, Li Zeng, Li Zeng, Li Zeng   +8 more
doaj   +1 more source

Replicator Dynamics of of Cancer Stem Cell; Selection in the Presence of Differentiation and Plasticity [PDF]

arXiv, 2014
Stem cells have the potential to produce lineages of non-stem cell populations (differentiated cells) via a ubiquitous hierarchal division scheme. Differentiation of a stem cell into (partially) differentiated cells can happen either symmetrically or asymmetrically. The selection dynamics of a mutant cancer stem cell should be investigated in the light
arxiv  

Predicting Neural Stem Cell Differentiation Using Deep Learning Models

, 2023
Neural stem cells have immense therapeutic potential for treating various neurological disorders. However, lengthy differentiation protocols hinder the translation of neural stem cells into clinical applications. In this study, we present a deep learning
Chen, Ian Young, Jalihal, Ananya, Mittal, Anika, Parthasarathy, Nidhi, Suda, Chandra   +4 more
core  

Differentiation of multipotent vascular stem cells contributes to vascular diseases. [PDF]

, 2012
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases.
Chu, Julia S, Helms, Jill A, Li, Song, Liu, Bo, Tang, Zhenyu, Wang, Aijun, Yan, Zhiqiang, Yuan, Falei   +7 more
core   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

Modeling tumorspheres reveals cancer stem cell niche building and plasticity [PDF]

, 2019
Cancer stem cells have been shown to be critical to the development of a variety of solid cancers. The precise interplay mechanisms between cancer stem cells and the rest of a tissue are still not elucidated. To shed light on the interactions between stem and non-stem cancer cell populations we develop a two-population mathematical model, which is ...
arxiv   +1 more source

An ependymal cell quest : identification and functional role of spinal cord neural stem cells [PDF]

, 2014
Few injuries have as profound and long-lasting consequences as spinal cord injury. The primary areas of impaired function typically include sensation, mobility, bladder, bowel and sexual function.
Sabelström, Hanna
core   +1 more source